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Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.
Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wollebæk Johannesen S, Göricke B; RAS-ALS Study Group. Ludolph AC, et al. Among authors: dupuis l. Lancet Neurol. 2018 Aug;17(8):681-688. doi: 10.1016/S1474-4422(18)30176-5. Epub 2018 Jun 19. Lancet Neurol. 2018. PMID: 29934198 Clinical Trial.
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Braunstein KE, Eschbach J, Ròna-Vörös K, Soylu R, Mikrouli E, Larmet Y, René F, Gonzalez De Aguilar JL, Loeffler JP, Müller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstöcker B, Kassubek J, Pichler B, Stiller D, Petersen A, Ludolph AC, Dupuis L. Braunstein KE, et al. Among authors: dupuis l. Hum Mol Genet. 2010 Nov 15;19(22):4385-98. doi: 10.1093/hmg/ddq361. Epub 2010 Aug 31. Hum Mol Genet. 2010. PMID: 20807776 Free PMC article.
Energy metabolism in amyotrophic lateral sclerosis.
Dupuis L, Pradat PF, Ludolph AC, Loeffler JP. Dupuis L, et al. Lancet Neurol. 2011 Jan;10(1):75-82. doi: 10.1016/S1474-4422(10)70224-6. Epub 2010 Oct 27. Lancet Neurol. 2011. PMID: 21035400 Review.
A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis.
Dupuis L, Dengler R, Heneka MT, Meyer T, Zierz S, Kassubek J, Fischer W, Steiner F, Lindauer E, Otto M, Dreyhaupt J, Grehl T, Hermann A, Winkler AS, Bogdahn U, Benecke R, Schrank B, Wessig C, Grosskreutz J, Ludolph AC; GERP ALS Study Group. Dupuis L, et al. PLoS One. 2012;7(6):e37885. doi: 10.1371/journal.pone.0037885. Epub 2012 Jun 8. PLoS One. 2012. PMID: 22715372 Free PMC article. Clinical Trial.
502 results