Lentzsch S - Search Results

1

Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation.

Liu A, Li S, Donnenberg V, Fu J, Gollin SM, Ma H, Lu C, Stolz DB, Mapara MY, Monaghan SA, Lentzsch S. Liu A, et al. Among authors: lentzsch s. Haematologica. 2018 Oct;103(10):1688-1697. doi: 10.3324/haematol.2018.188227. Epub 2018 Jun 28. Haematologica. 2018. PMID: 29954930 Free PMC article.

2

Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.

Lentzsch S, Gries M, Janz M, Bargou R, Dörken B, Mapara MY. Lentzsch S, et al. Blood. 2003 May 1;101(9):3568-73. doi: 10.1182/blood-2002-08-2383. Epub 2002 Dec 27. Blood. 2003. PMID: 12506012 Free article.

3

Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.

Koh KR, Janz M, Mapara MY, Lemke B, Stirling D, Dörken B, Zenke M, Lentzsch S. Koh KR, et al. Among authors: lentzsch s. Blood. 2005 May 15;105(10):3833-40. doi: 10.1182/blood-2004-03-0828. Epub 2004 Aug 3. Blood. 2005. PMID: 15292067 Free article.

4

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1.

Anderson G, Gries M, Kurihara N, Honjo T, Anderson J, Donnenberg V, Donnenberg A, Ghobrial I, Mapara MY, Stirling D, Roodman D, Lentzsch S. Anderson G, et al. Among authors: lentzsch s. Blood. 2006 Apr 15;107(8):3098-105. doi: 10.1182/blood-2005-08-3450. Epub 2005 Dec 22. Blood. 2006. PMID: 16373662 Free article.

5

Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.

Leng C, Gries M, Ziegler J, Lokshin A, Mascagni P, Lentzsch S, Mapara MY. Leng C, et al. Among authors: lentzsch s. Exp Hematol. 2006 Jun;34(6):776-87. doi: 10.1016/j.exphem.2006.02.014. Exp Hematol. 2006. PMID: 16728283 Free article.

6

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-kappaB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth.

Feng R, Anderson G, Xiao G, Elliott G, Leoni L, Mapara MY, Roodman GD, Lentzsch S. Feng R, et al. Among authors: lentzsch s. Blood. 2007 Mar 1;109(5):2130-8. doi: 10.1182/blood-2006-07-027458. Epub 2006 Nov 9. Blood. 2007. PMID: 17095620 Free article.

7

The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage.

Feng R, Oton A, Mapara MY, Anderson G, Belani C, Lentzsch S. Feng R, et al. Among authors: lentzsch s. Br J Haematol. 2007 Nov;139(3):385-97. doi: 10.1111/j.1365-2141.2007.06772.x. Br J Haematol. 2007. PMID: 17910628 Free article.

8

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling.

Feng R, Ma H, Hassig CA, Payne JE, Smith ND, Mapara MY, Hager JH, Lentzsch S. Feng R, et al. Among authors: lentzsch s. Mol Cancer Ther. 2008 Jun;7(6):1494-505. doi: 10.1158/1535-7163.MCT-08-0183. Mol Cancer Ther. 2008. PMID: 18566220

9

C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells.

Pal R, Janz M, Galson DL, Gries M, Li S, Jöhrens K, Anagnostopoulos I, Dörken B, Mapara MY, Borghesi L, Kardava L, Roodman GD, Milcarek C, Lentzsch S. Pal R, et al. Among authors: lentzsch s. Blood. 2009 Oct 29;114(18):3890-8. doi: 10.1182/blood-2009-01-201111. Epub 2009 Aug 28. Blood. 2009. PMID: 19717648 Free PMC article.

10

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia.

Pal R, Monaghan SA, Hassett AC, Mapara MY, Schafer P, Roodman GD, Ragni MV, Moscinski L, List A, Lentzsch S. Pal R, et al. Among authors: lentzsch s. Blood. 2010 Jan 21;115(3):605-14. doi: 10.1182/blood-2009-05-221077. Epub 2009 Nov 25. Blood. 2010. PMID: 19965623 Free article.

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