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An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.
Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, Bousquet E, Downward J, Maraver A, Krizhanovsky V, Yarden Y. Mancini M, et al. Among authors: noronha a. EMBO Mol Med. 2018 Feb;10(2):294-308. doi: 10.15252/emmm.201708076. EMBO Mol Med. 2018. PMID: 29212784 Free PMC article.
Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors.
Haga Y, Marrocco I, Noronha A, Uribe ML, Nataraj NB, Sekar A, Drago-Garcia D, Borgoni S, Lindzen M, Giri S, Wiemann S, Tsutsumi Y, Yarden Y. Haga Y, et al. Among authors: noronha a. Cancer Res. 2021 Jul 15;81(14):3862-3875. doi: 10.1158/0008-5472.CAN-20-3555. Epub 2021 May 3. Cancer Res. 2021. PMID: 33941614 Free PMC article.
SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.
Roth L, Srivastava S, Lindzen M, Sas-Chen A, Sheffer M, Lauriola M, Enuka Y, Noronha A, Mancini M, Lavi S, Tarcic G, Pines G, Nevo N, Heyman O, Ziv T, Rueda OM, Gnocchi D, Pikarsky E, Admon A, Caldas C, Yarden Y. Roth L, et al. Among authors: noronha a. Sci Signal. 2018 Jan 30;11(515):eaan0949. doi: 10.1126/scisignal.aan0949. Sci Signal. 2018. PMID: 29382783
Irreversible modifications of receptor tyrosine kinases.
Kreitman M, Noronha A, Yarden Y. Kreitman M, et al. Among authors: noronha a. FEBS Lett. 2018 Jul;592(13):2199-2212. doi: 10.1002/1873-3468.13095. Epub 2018 May 28. FEBS Lett. 2018. PMID: 29790151 Free article. Review.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Lindzen M, Ghosh S, Noronha A, Drago D, Nataraj NB, Leitner O, Carvalho S, Zmora E, Sapoznik S, Shany KB, Levanon K, Aderka D, Ramírez BS, Dahlhoff M, McNeish I, Yarden Y. Lindzen M, et al. Among authors: noronha a. Oncogene. 2021 May;40(21):3665-3679. doi: 10.1038/s41388-021-01784-8. Epub 2021 Apr 30. Oncogene. 2021. PMID: 33941851 Free PMC article.
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Ghosh S, Nataraj NB, Noronha A, Patkar S, Sekar A, Mukherjee S, Winograd-Katz S, Kramarski L, Verma A, Lindzen M, Garcia DD, Green J, Eisenberg G, Gil-Henn H, Basu A, Lender Y, Weiss S, Oren M, Lotem M, Geiger B, Ruppin E, Yarden Y. Ghosh S, et al. Among authors: noronha a. Cell Rep. 2021 May 25;35(8):109181. doi: 10.1016/j.celrep.2021.109181. Cell Rep. 2021. PMID: 34038737 Free PMC article.
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer.
Noronha A, Belugali Nataraj N, Lee JS, Zhitomirsky B, Oren Y, Oster S, Lindzen M, Mukherjee S, Will R, Ghosh S, Simoni-Nieves A, Verma A, Chatterjee R, Borgoni S, Robinson W, Sinha S, Brandis A, Kerr DL, Wu W, Sekar A, Giri S, Chung Y, Drago-Garcia D, Danysh BP, Lauriola M, Fiorentino M, Ardizzoni A, Oren M, Blakely CM, Ezike J, Wiemann S, Parida L, Bivona TG, Aqeilan RI, Brugge JS, Regev A, Getz G, Ruppin E, Yarden Y. Noronha A, et al. Cancer Discov. 2022 Nov 2;12(11):2666-2683. doi: 10.1158/2159-8290.CD-22-0111. Cancer Discov. 2022. PMID: 35895872 Free PMC article.
279 results