Hercus TR - Search Results

1

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

Dhagat U, Hercus TR, Broughton SE, Nero TL, Cheung Tung Shing KS, Barry EF, Thomson CA, Bryson S, Pai EF, McClure BJ, Schrader JW, Lopez AF, Parker MW. Dhagat U, et al. Among authors: hercus tr. MAbs. 2018 Oct;10(7):1018-1029. doi: 10.1080/19420862.2018.1494107. Epub 2018 Sep 12. MAbs. 2018. PMID: 29969365 Free PMC article.

2

Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

Lopez AF, Shannon MF, Hercus T, Nicola NA, Cambareri B, Dottore M, Layton MJ, Eglinton L, Vadas MA. Lopez AF, et al. EMBO J. 1992 Mar;11(3):909-16. doi: 10.1002/j.1460-2075.1992.tb05129.x. EMBO J. 1992. PMID: 1532144 Free PMC article.

3

Interaction of GM-CSF and IL-3 with the common beta-chain of their receptors.

Bagley CJ, Woodcock JM, Hercus TR, Shannon MF, Lopez AF. Bagley CJ, et al. Among authors: hercus tr. J Leukoc Biol. 1995 May;57(5):739-46. doi: 10.1002/jlb.57.5.739. J Leukoc Biol. 1995. PMID: 7759954 Review.

4

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF. Woodcock JM, et al. Among authors: hercus tr. EMBO J. 1994 Nov 1;13(21):5176-85. doi: 10.1002/j.1460-2075.1994.tb06848.x. EMBO J. 1994. PMID: 7957082 Free PMC article.

5

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

Hercus TR, Bagley CJ, Cambareri B, Dottore M, Woodcock JM, Vadas MA, Shannon MF, Lopez AF. Hercus TR, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5838-42. doi: 10.1073/pnas.91.13.5838. Proc Natl Acad Sci U S A. 1994. PMID: 8016076 Free PMC article.

6

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor.

Hercus TR, Cambareri B, Dottore M, Woodcock J, Bagley CJ, Vadas MA, Shannon MF, Lopez AF. Hercus TR, et al. Blood. 1994 Jun 15;83(12):3500-8. Blood. 1994. PMID: 8204877 Free article.

7

The apoptosis-inducing granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor and requires interleukin-1beta-converting enzyme-like proteases.

Iversen PO, Hercus TR, Zacharakis B, Woodcock JM, Stomski FC, Kumar S, Nelson BH, Miyajima A, Lopez AF. Iversen PO, et al. Among authors: hercus tr. J Biol Chem. 1997 Apr 11;272(15):9877-83. doi: 10.1074/jbc.272.15.9877. J Biol Chem. 1997. PMID: 9092524 Free article.

8

Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition.

Rajotte D, Cadieux C, Haman A, Wilkes BC, Clark SC, Hercus T, Woodcock JA, Lopez A, Hoang T. Rajotte D, et al. J Exp Med. 1997 Jun 2;185(11):1939-50. doi: 10.1084/jem.185.11.1939. J Exp Med. 1997. PMID: 9166423 Free PMC article.

9

Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly.

Haman A, Cadieux C, Wilkes B, Hercus T, Lopez A, Clark S, Hoang T. Haman A, et al. J Biol Chem. 1999 Nov 26;274(48):34155-63. doi: 10.1074/jbc.274.48.34155. J Biol Chem. 1999. PMID: 10567387 Free article.

10

Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist.

Rossjohn J, McKinstry WJ, Woodcock JM, McClure BJ, Hercus TR, Parker MW, Lopez AF, Bagley CJ. Rossjohn J, et al. Among authors: hercus tr. Blood. 2000 Apr 15;95(8):2491-8. Blood. 2000. PMID: 10753826 Free article.

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