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Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, Hodges HC, Debyser Z, Veverka V. Sharma S, et al. Among authors: van belle s. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7053-E7062. doi: 10.1073/pnas.1803909115. Epub 2018 Jul 11. Proc Natl Acad Sci U S A. 2018. PMID: 29997176 Free PMC article.
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J. El Ashkar S, et al. Among authors: van belle s, van vlierberghe p. Blood. 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30. Blood. 2018. PMID: 29084774 Free PMC article.
BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis.
Nombela I, Michiels M, Van Looveren D, Marcelis L, El Ashkar S, Van Belle S, Bruggemans A, Tousseyn T, Schwaller J, Christ F, Gijsbers R, De Rijck J, Debyser Z. Nombela I, et al. Among authors: van belle s, van looveren d. Microbiol Spectr. 2022 Aug 31;10(4):e0147822. doi: 10.1128/spectrum.01478-22. Epub 2022 Jul 19. Microbiol Spectr. 2022. PMID: 35852337 Free PMC article.
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Vantieghem T, Aslam NA, Osipov EM, Akele M, Van Belle S, Beelen S, Drexler M, Paulovcakova T, Lux V, Fearon D, Douangamath A, von Delft F, Christ F, Veverka V, Verwilst P, Van Aerschot A, Debyser Z, Strelkov SV. Vantieghem T, et al. Among authors: van belle s. Eur J Med Chem. 2024 Dec 15;280:116960. doi: 10.1016/j.ejmech.2024.116960. Epub 2024 Oct 11. Eur J Med Chem. 2024. PMID: 39461037
309 results