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Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
García-León JA, Cabrera-Socorro A, Eggermont K, Swijsen A, Terryn J, Fazal R, Nami F, Ordovás L, Quiles A, Lluis F, Serneels L, Wierda K, Sierksma A, Kreir M, Pestana F, Van Damme P, De Strooper B, Thorrez L, Ebneth A, Verfaillie CM. García-León JA, et al. Among authors: thorrez l. Alzheimers Dement. 2018 Oct;14(10):1261-1280. doi: 10.1016/j.jalz.2018.05.007. Epub 2018 Jul 20. Alzheimers Dement. 2018. PMID: 30036493 Free article.
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.
Patel AM, Wierda K, Thorrez L, van Putten M, De Smedt J, Ribeiro L, Tricot T, Gajjar M, Duelen R, Van Damme P, De Waele L, Goemans N, Tanganyika-de Winter C, Costamagna D, Aartsma-Rus A, van Duyvenvoorde H, Sampaolesi M, Buyse GM, Verfaillie CM. Patel AM, et al. Among authors: thorrez l. Transl Psychiatry. 2019 Aug 21;9(1):200. doi: 10.1038/s41398-019-0535-1. Transl Psychiatry. 2019. PMID: 31434868 Free PMC article.
FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms.
Stoklund Dittlau K, Terrie L, Baatsen P, Kerstens A, De Swert L, Janky R, Corthout N, Masrori P, Van Damme P, Hyttel P, Meyer M, Thorrez L, Freude K, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: thorrez l. Mol Neurodegener. 2023 Jan 18;18(1):5. doi: 10.1186/s13024-022-00591-3. Mol Neurodegener. 2023. PMID: 36653804 Free PMC article.
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
Quattrocelli M, Swinnen M, Giacomazzi G, Camps J, Barthélemy I, Ceccarelli G, Caluwé E, Grosemans H, Thorrez L, Pelizzo G, Muijtjens M, Verfaillie CM, Blot S, Janssens S, Sampaolesi M. Quattrocelli M, et al. Among authors: thorrez l. J Clin Invest. 2015 Dec;125(12):4463-82. doi: 10.1172/JCI82735. Epub 2015 Nov 16. J Clin Invest. 2015. PMID: 26571398 Free PMC article.
75 results