van den Berg RJBHN - Search Results

1

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors.

Deng H, van der Wel T, van den Berg RJBHN, van den Nieuwendijk AMCH, Janssen FJ, Baggelaar MP, Overkleeft HS, van der Stelt M. Deng H, et al. Medchemcomm. 2017 Mar 10;8(5):982-988. doi: 10.1039/c7md00029d. eCollection 2017 May 1. Medchemcomm. 2017. PMID: 30108813 Free PMC article.

2

Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.

van den Nieuwendijk AM, Ruben M, Engelsma SE, Risseeuw MD, van den Berg RJ, Boot RG, Aerts JM, Brussee J, van der Marel GA, Overkleeft HS. van den Nieuwendijk AM, et al. Org Lett. 2010 Sep 3;12(17):3957-9. doi: 10.1021/ol101556k. Org Lett. 2010. PMID: 20690611

3

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, Overkleeft HS. Ghisaidoobe AT, et al. J Med Chem. 2014 Nov 13;57(21):9096-104. doi: 10.1021/jm501181z. Epub 2014 Oct 17. J Med Chem. 2014. PMID: 25250725

4

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

Wisse P, de Geus MA, Cross G, van den Nieuwendijk AM, van Rooden EJ, van den Berg RJ, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS. Wisse P, et al. J Org Chem. 2015 Jul 17;80(14):7258-65. doi: 10.1021/acs.joc.5b00823. Epub 2015 Jun 25. J Org Chem. 2015. PMID: 26061009

5

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M. Deng H, et al. J Med Chem. 2017 Jan 12;60(1):428-440. doi: 10.1021/acs.jmedchem.6b01482. Epub 2016 Dec 19. J Med Chem. 2017. PMID: 27992221

6

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Lahav D, et al. J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29. J Am Chem Soc. 2017. PMID: 28937220 Free PMC article.

7

Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6.

van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk AMCH, Janssen APA, van den Berg RJBHN, Overkleeft HS, van der Stelt M. van Rooden EJ, et al. Chem Asian J. 2018 Nov 16;13(22):3491-3500. doi: 10.1002/asia.201800452. Epub 2018 Jun 14. Chem Asian J. 2018. PMID: 29901868

8

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ^8/9-Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells.

Soethoudt M, Alachouzos G, van Rooden EJ, Moya-Garzón MD, van den Berg RJBHN, Heitman LH, van der Stelt M. Soethoudt M, et al. Among authors: van den berg rjbhn. Cannabis Cannabinoid Res. 2018 Jul 1;3(1):136-151. doi: 10.1089/can.2018.0003. eCollection 2018. Cannabis Cannabinoid Res. 2018. PMID: 29992186 Free PMC article.

9

Two-step activity-based protein profiling of diacylglycerol lipase.

van Rooden EJ, Kreekel R, Hansen T, Janssen APA, van Esbroeck ACM, den Dulk H, van den Berg RJBHN, Codée JDC, van der Stelt M. van Rooden EJ, et al. Among authors: van den berg rjbhn. Org Biomol Chem. 2018 Jul 25;16(29):5250-5253. doi: 10.1039/c8ob01499j. Org Biomol Chem. 2018. PMID: 30004552

10

A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals.

Rugen MD, Vernet MMJL, Hantouti L, Soenens A, Andriotis VME, Rejzek M, Brett P, van den Berg RJBHN, Aerts JMFG, Overkleeft HS, Field RA. Rugen MD, et al. Among authors: van den berg rjbhn. Sci Rep. 2018 Nov 6;8(1):16421. doi: 10.1038/s41598-018-34749-1. Sci Rep. 2018. PMID: 30401902 Free PMC article.

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