Wu XN - Search Results

1

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors.

Wu XN, Huang YD, Li JX, Yu YF, Qian Z, Zhang C, Wu Y, Luo HB. Wu XN, et al. Among authors: wu y. Acta Pharm Sin B. 2018 Jul;8(4):615-628. doi: 10.1016/j.apsb.2017.12.007. Epub 2018 Mar 12. Acta Pharm Sin B. 2018. PMID: 30109185 Free PMC article.

2

Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia.

Wu XN, Zhou Q, Huang YD, Xie X, Li Z, Wu Y, Luo HB. Wu XN, et al. Among authors: wu y. Acta Pharm Sin B. 2022 Jul;12(7):3103-3112. doi: 10.1016/j.apsb.2022.02.012. Epub 2022 Feb 22. Acta Pharm Sin B. 2022. PMID: 35865094 Free PMC article.

3

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.

Yu YF, Huang YD, Zhang C, Wu XN, Zhou Q, Wu D, Wu Y, Luo HB. Yu YF, et al. Among authors: wu y, wu d, wu xn. ACS Chem Neurosci. 2017 Nov 15;8(11):2522-2534. doi: 10.1021/acschemneuro.7b00268. Epub 2017 Aug 23. ACS Chem Neurosci. 2017. PMID: 28783948

4

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease.

Zhang C, Zhou Q, Wu XN, Huang YD, Zhou J, Lai Z, Wu Y, Luo HB. Zhang C, et al. Among authors: wu y, wu xn. J Enzyme Inhib Med Chem. 2018 Dec;33(1):260-270. doi: 10.1080/14756366.2017.1412315. J Enzyme Inhib Med Chem. 2018. PMID: 29271265 Free PMC article.

5

Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.

Huang Y, Wu XN, Zhou Q, Wu Y, Zheng D, Li Z, Guo L, Luo HB. Huang Y, et al. Among authors: wu y, wu xn. J Med Chem. 2020 Dec 24;63(24):15852-15863. doi: 10.1021/acs.jmedchem.0c01573. Epub 2020 Dec 8. J Med Chem. 2020. PMID: 33291877

6

A novel inhibitor of N ⁶-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities.

Xie G, Wu XN, Ling Y, Rui Y, Wu D, Zhou J, Li J, Lin S, Peng Q, Li Z, Wang H, Luo HB. Xie G, et al. Among authors: wu d, wu xn. Acta Pharm Sin B. 2022 Feb;12(2):853-866. doi: 10.1016/j.apsb.2021.08.028. Epub 2021 Aug 31. Acta Pharm Sin B. 2022. PMID: 35256950 Free PMC article.

7

Free energy perturbation (FEP)-guided scaffold hopping.

Wu D, Zheng X, Liu R, Li Z, Jiang Z, Zhou Q, Huang Y, Wu XN, Zhang C, Huang YY, Luo HB. Wu D, et al. Among authors: wu xn. Acta Pharm Sin B. 2022 Mar;12(3):1351-1362. doi: 10.1016/j.apsb.2021.09.027. Epub 2021 Sep 30. Acta Pharm Sin B. 2022. PMID: 35530128 Free PMC article.

8

Effects of Different Types of Microplastics on Cold Seep Microbial Diversity and Function.

Wu XN, Feng JC, Chen X, Lin YL, Huang Y, Zhong S, Li CR, Zhu MZ, Zhang S. Wu XN, et al. Environ Sci Technol. 2025 Jan 6. doi: 10.1021/acs.est.4c08102. Online ahead of print. Environ Sci Technol. 2025. PMID: 39763234

9

A PRA-Rab trafficking machinery modulates NLR immune receptor plasma membrane microdomain anchoring and blast resistance in rice.

Liang D, Yang D, Li T, Zhu Z, Yan B, He Y, Li X, Zhai K, Liu J, Kawano Y, Deng Y, Wu XN, Liu J, He Z. Liang D, et al. Among authors: wu xn. Sci Bull (Beijing). 2024 Dec 9:S2095-9273(24)00911-3. doi: 10.1016/j.scib.2024.12.007. Online ahead of print. Sci Bull (Beijing). 2024. PMID: 39736493 Free article.

10

[The distributions of serum HBsAg level in chronic hepatitis B patients based on the China Registry of Hepatitis B (CR-HepB)].

Chen SY, Shan S, Kong YY, Xu XQ, Wang H, Wu XN, Zhou JL, Wang BQ, Meng TT, Zhang MY, Jia JD, Sun YM, You H. Chen SY, et al. Among authors: wu xn. Zhonghua Gan Zang Bing Za Zhi. 2024 Dec 27;32:1-7. doi: 10.3760/cma.j.cn501113-20240723-00337. Online ahead of print. Zhonghua Gan Zang Bing Za Zhi. 2024. PMID: 39734097 Chinese.

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