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Activating PI3-kinase to dampen inflammation.
Kok BP, Saez E. Kok BP, et al. Among authors: saez e. Chem Biol. 2014 Aug 14;21(8):917-8. doi: 10.1016/j.chembiol.2014.07.012. Chem Biol. 2014. PMID: 25126986 Free PMC article.
The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans.
Finlin BS, Zhu B, Kok BP, Godio C, Westgate PM, Grayson N, Sims R, Bland JS, Saez E, Kern PA. Finlin BS, et al. Among authors: saez e. Front Endocrinol (Lausanne). 2017 Sep 29;8:255. doi: 10.3389/fendo.2017.00255. eCollection 2017. Front Endocrinol (Lausanne). 2017. PMID: 29033896 Free PMC article.
PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, Peluso JJ, Pru JK, Siuzdak G, Cravatt BF, Saez E. Galmozzi A, et al. Among authors: saez e. Nature. 2019 Dec;576(7785):138-142. doi: 10.1038/s41586-019-1774-2. Epub 2019 Nov 20. Nature. 2019. PMID: 31748741 Free PMC article.
Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss.
Cintron-Colon R, Johnson CW, Montenegro-Burke JR, Guijas C, Faulhaber L, Sanchez-Alavez M, Aguirre CA, Shankar K, Singh M, Galmozzi A, Siuzdak G, Saez E, Conti B. Cintron-Colon R, et al. Among authors: saez e. Curr Biol. 2019 Dec 16;29(24):4291-4299.e4. doi: 10.1016/j.cub.2019.10.027. Epub 2019 Nov 27. Curr Biol. 2019. PMID: 31786059 Free PMC article.
Discovery of small-molecule enzyme activators by activity-based protein profiling.
Kok BP, Ghimire S, Kim W, Chatterjee S, Johns T, Kitamura S, Eberhardt J, Ogasawara D, Xu J, Sukiasyan A, Kim SM, Godio C, Bittencourt JM, Cameron M, Galmozzi A, Forli S, Wolan DW, Cravatt BF, Boger DL, Saez E. Kok BP, et al. Among authors: saez e. Nat Chem Biol. 2020 Sep;16(9):997-1005. doi: 10.1038/s41589-020-0555-4. Epub 2020 Jun 8. Nat Chem Biol. 2020. PMID: 32514184 Free PMC article.
157 results