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The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.
Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ. Paxman JJ, et al. Among authors: kahler cm. J Biol Chem. 2009 Jun 26;284(26):17835-45. doi: 10.1074/jbc.M109.011502. Epub 2009 Apr 22. J Biol Chem. 2009. PMID: 19389711 Free PMC article.
Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.
Smith RP, Whitten AE, Paxman JJ, Kahler CM, Scanlon MJ, Heras B. Smith RP, et al. Among authors: kahler cm. Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):31-38. doi: 10.1107/S2053230X17017800. Epub 2018 Jan 1. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29372905 Free PMC article.
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis.
Vivian JP, Scoullar J, Robertson AL, Bottomley SP, Horne J, Chin Y, Wielens J, Thompson PE, Velkov T, Piek S, Byres E, Beddoe T, Wilce MC, Kahler CM, Rossjohn J, Scanlon MJ. Vivian JP, et al. Among authors: kahler cm. J Biol Chem. 2008 Nov 21;283(47):32452-61. doi: 10.1074/jbc.M803990200. Epub 2008 Aug 20. J Biol Chem. 2008. PMID: 18715864 Free article.
Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis.
Vivian JP, Scoullar J, Rimmer K, Bushell SR, Beddoe T, Wilce MC, Byres E, Boyle TP, Doak B, Simpson JS, Graham B, Heras B, Kahler CM, Rossjohn J, Scanlon MJ. Vivian JP, et al. Among authors: kahler cm. J Mol Biol. 2009 Dec 18;394(5):931-43. doi: 10.1016/j.jmb.2009.09.065. Epub 2009 Oct 6. J Mol Biol. 2009. PMID: 19815019
The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.
Piek S, Wang Z, Ganguly J, Lakey AM, Bartley SN, Mowlaboccus S, Anandan A, Stubbs KA, Scanlon MJ, Vrielink A, Azadi P, Carlson RW, Kahler CM. Piek S, et al. Among authors: kahler cm. PLoS One. 2014 Sep 12;9(9):e106513. doi: 10.1371/journal.pone.0106513. eCollection 2014. PLoS One. 2014. PMID: 25215579 Free PMC article.
Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM. Mullally C, et al. Among authors: kahler cm. J Antimicrob Chemother. 2022 Aug 25;77(9):2441-2447. doi: 10.1093/jac/dkac204. J Antimicrob Chemother. 2022. PMID: 35770844 Free PMC article.
158 results