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722 results

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Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA.
Adams LA, Sharma P, Mohanty B, Ilyichova OV, Mulcair MD, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Horne J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B, Simpson JS, Scanlon MJ. Adams LA, et al. Among authors: williams ml. Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2179-84. doi: 10.1002/anie.201410341. Epub 2014 Dec 30. Angew Chem Int Ed Engl. 2015. PMID: 25556635
A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists.
Patil R, Mohanty B, Liu B, Chandrashekaran IR, Headey SJ, Williams ML, Clements CS, Ilyichova O, Doak BC, Genissel P, Weaver RJ, Vuillard L, Halls ML, Porter CJH, Scanlon MJ. Patil R, et al. Among authors: williams ml. J Biol Chem. 2019 Mar 8;294(10):3720-3734. doi: 10.1074/jbc.RA118.006848. Epub 2018 Dec 31. J Biol Chem. 2019. PMID: 30598509 Free PMC article.
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX).
Bentley MR, Ilyichova OV, Wang G, Williams ML, Sharma G, Alwan WS, Whitehouse RL, Mohanty B, Scammells PJ, Heras B, Martin JL, Totsika M, Capuano B, Doak BC, Scanlon MJ. Bentley MR, et al. Among authors: williams ml. J Med Chem. 2020 Jul 9;63(13):6863-6875. doi: 10.1021/acs.jmedchem.0c00111. Epub 2020 Jun 24. J Med Chem. 2020. PMID: 32529824
NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide-dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei.
Nebl S, Alwan WS, Williams ML, Sharma G, Taylor A, Doak BC, Wilde KL, McMahon RM, Halili MA, Martin JL, Capuano B, Fenwick RB, Mohanty B, Scanlon MJ. Nebl S, et al. Among authors: williams ml. J Biomol NMR. 2020 Nov;74(10-11):595-611. doi: 10.1007/s10858-020-00339-5. Epub 2020 Aug 6. J Biomol NMR. 2020. PMID: 32761504
Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials.
Wang G, Mohanty B, Williams ML, Doak BC, Dhouib R, Totsika M, McMahon RM, Sharma G, Zheng D, Bentley MR, Ka-Yan Chin Y, Horne J, Chalmers DK, Heras B, Scanlon MJ. Wang G, et al. Among authors: williams ml. ChemMedChem. 2022 Mar 18;17(6):e202100673. doi: 10.1002/cmdc.202100673. Epub 2022 Jan 27. ChemMedChem. 2022. PMID: 34978144 Free PMC article.
722 results