Walther TC - Search Results

1

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.

Singh S, Dransfeld UE, Ambaw YA, Lopez-Scarim J, Farese RV Jr, Walther TC. Singh S, et al. Among authors: walther tc. Cell. 2024 Nov 27;187(24):6820-6834.e24. doi: 10.1016/j.cell.2024.09.036. Epub 2024 Oct 17. Cell. 2024. PMID: 39423811 Free article.

2

Carboxy-terminal blockade of sortilin binding enhances progranulin gene therapy, a potential treatment for frontotemporal dementia.

Kashyap SN, Fox SN, Wilson KI, Murchison CF, Ambaw YA, Walther TC, Farese RV, Arrant AE, Roberson ED. Kashyap SN, et al. Among authors: walther tc. bioRxiv [Preprint]. 2024 Sep 16:2024.09.15.613118. doi: 10.1101/2024.09.15.613118. bioRxiv. 2024. PMID: 39345608 Free PMC article. Preprint.

3

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.

Vicidomini C, Goode TD, McAvoy KM, Yu R, Beveridge CH, Iyer SN, Victor MB, Leary N, Evans L, Steinbaugh MJ, Lai ZW, Lyon MC, Silvestre MRFS, Bonilla G, Sadreyev RI, Walther TC, Sui SH, Saido T, Yamamoto K, Murakami M, Tsai LH, Chopra G, Sahay A. Vicidomini C, et al. Among authors: walther tc. bioRxiv [Preprint]. 2024 Sep 3:2024.07.26.605338. doi: 10.1101/2024.07.26.605338. bioRxiv. 2024. PMID: 39211220 Free PMC article. Preprint.

4

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.

Singh S, Dransfeld U, Ambaw Y, Lopez-Scarim J, Farese RV Jr, Walther TC. Singh S, et al. Among authors: walther tc. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586175. doi: 10.1101/2024.03.21.586175. bioRxiv. 2024. Update in: Cell. 2024 Nov 27;187(24):6820-6834.e24. doi: 10.1016/j.cell.2024.09.036 PMID: 38562702 Free PMC article. Updated. Preprint.

5

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity.

Chitraju C, Fischer AW, Ambaw YA, Wang K, Yuan B, Hui S, Walther TC, Farese RV Jr. Chitraju C, et al. Among authors: walther tc. Elife. 2023 Oct 2;12:RP88049. doi: 10.7554/eLife.88049. Elife. 2023. PMID: 37782317 Free PMC article.

6

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.

Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Zhang J, Walther TC, Farese RV Jr. Chung J, et al. Among authors: walther tc. Nat Cell Biol. 2023 Aug;25(8):1101-1110. doi: 10.1038/s41556-023-01178-w. Epub 2023 Jul 13. Nat Cell Biol. 2023. PMID: 37443287 Free PMC article.

7

The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification.

Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Liao M, Walther TC, Farese RV Jr. Wang K, et al. Among authors: walther tc. Nat Commun. 2023 Jun 14;14(1):3533. doi: 10.1038/s41467-023-38932-5. Nat Commun. 2023. PMID: 37316513 Free PMC article.

8

Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.

Sui X, Wang K, Song K, Xu C, Song J, Lee CW, Liao M, Farese RV Jr, Walther TC. Sui X, et al. Among authors: walther tc. Nat Commun. 2023 May 29;14(1):3100. doi: 10.1038/s41467-023-38934-3. Nat Commun. 2023. PMID: 37248213 Free PMC article.

9

Structure and function of lipid droplet assembly complexes.

Walther TC, Kim S, Arlt H, Voth GA, Farese RV Jr. Walther TC, et al. Curr Opin Struct Biol. 2023 Jun;80:102606. doi: 10.1016/j.sbi.2023.102606. Epub 2023 May 5. Curr Opin Struct Biol. 2023. PMID: 37150040 Free PMC article. Review.

10

Fitm2 is required for ER homeostasis and normal function of murine liver.

Bond LM, Ibrahim A, Lai ZW, Walzem RL, Bronson RT, Ilkayeva OR, Walther TC, Farese RV Jr. Bond LM, et al. Among authors: walther tc. J Biol Chem. 2023 Mar;299(3):103022. doi: 10.1016/j.jbc.2023.103022. Epub 2023 Feb 15. J Biol Chem. 2023. PMID: 36805337 Free PMC article.

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