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The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C. Neumann U, et al. Among authors: graf a. EMBO Mol Med. 2018 Nov;10(11):e9316. doi: 10.15252/emmm.201809316. EMBO Mol Med. 2018. PMID: 30224383 Free PMC article. Clinical Trial.
The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease.
Lopez Lopez C, Tariot PN, Caputo A, Langbaum JB, Liu F, Riviere ME, Langlois C, Rouzade-Dominguez ML, Zalesak M, Hendrix S, Thomas RG, Viglietta V, Lenz R, Ryan JM, Graf A, Reiman EM. Lopez Lopez C, et al. Among authors: graf a. Alzheimers Dement (N Y). 2019 Jun 12;5:216-227. doi: 10.1016/j.trci.2019.02.005. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31211217 Free PMC article. Review.
Reversibility of cognitive worsening observed with BACE inhibitor umibecestat in the Alzheimer's Prevention Initiative (API) Generation Studies.
Tariot PN, Riviere ME, Salloway S, Burns JM, Snaedal JG, Borowsky B, Lopez CL, Liu F, Rouzade-Dominguez ML, Cazorla P, Mousseau MC, Arkuszewski M, Ricart J, Viglietta V, Sui Y, Caputo A, Langbaum JB, Reiman EM, Graf A. Tariot PN, et al. Among authors: graf a. Alzheimers Dement. 2024 Nov;20(11):7745-7761. doi: 10.1002/alz.14237. Epub 2024 Sep 25. Alzheimers Dement. 2024. PMID: 39320017 Free PMC article. Clinical Trial.
Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
Winblad B, Andreasen N, Minthon L, Floesser A, Imbert G, Dumortier T, Maguire RP, Blennow K, Lundmark J, Staufenbiel M, Orgogozo JM, Graf A. Winblad B, et al. Among authors: graf a. Lancet Neurol. 2012 Jul;11(7):597-604. doi: 10.1016/S1474-4422(12)70140-0. Epub 2012 Jun 6. Lancet Neurol. 2012. PMID: 22677258 Clinical Trial.
Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer's disease.
Caputo A, Racine A, Paule I, Tariot PN, Langbaum JB, Coello N, Riviere ME, Ryan JM, Lopez CL, Graf A; National Alzheimer’s Coordinating Center; Alzheimer’s Disease Neuroimaging Initiative. Caputo A, et al. Among authors: graf a. Alzheimers Res Ther. 2023 Mar 6;15(1):45. doi: 10.1186/s13195-023-01183-z. Alzheimers Res Ther. 2023. PMID: 36879340 Free PMC article.
Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer's Prevention Trial: A global Perspective from the API Generation Program.
Walsh T, Duff L, Riviere ME, Tariot PN, Doak K, Smith M, Borowsky B, Lopez Lopez C, Arratia PC, Liu F, Scholten I, Gordon D, Arbuckle J, Graf A, Quinn M, Ricart J, Langbaum JB. Walsh T, et al. Among authors: graf a. J Prev Alzheimers Dis. 2023;10(3):453-463. doi: 10.14283/jpad.2023.27. J Prev Alzheimers Dis. 2023. PMID: 37357285 Free PMC article. Clinical Trial.
Measuring cognition and function in the preclinical stage of Alzheimer's disease.
Weintraub S, Carrillo MC, Farias ST, Goldberg TE, Hendrix JA, Jaeger J, Knopman DS, Langbaum JB, Park DC, Ropacki MT, Sikkes SAM, Welsh-Bohmer KA, Bain LJ, Brashear R, Budur K, Graf A, Martenyi F, Storck MS, Randolph C. Weintraub S, et al. Among authors: graf a. Alzheimers Dement (N Y). 2018 Feb 13;4:64-75. doi: 10.1016/j.trci.2018.01.003. eCollection 2018. Alzheimers Dement (N Y). 2018. PMID: 29955653 Free PMC article. Review.
764 results