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De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.
Basilicata MF, Bruel AL, Semplicio G, Valsecchi CIK, Aktaş T, Duffourd Y, Rumpf T, Morton J, Bache I, Szymanski WG, Gilissen C, Vanakker O, Õunap K, Mittler G, van der Burgt I, El Chehadeh S, Cho MT, Pfundt R, Tan TY, Kirchhoff M, Menten B, Vergult S, Lindstrom K, Reis A, Johnson DS, Fryer A, McKay V; DDD Study; Fisher RB, Thauvin-Robinet C, Francis D, Roscioli T, Pajusalu S, Radtke K, Ganesh J, Brunner HG, Wilson M, Faivre L, Kalscheuer VM, Thevenon J, Akhtar A. Basilicata MF, et al. Among authors: aktas t. Nat Genet. 2018 Oct;50(10):1442-1451. doi: 10.1038/s41588-018-0220-y. Epub 2018 Sep 17. Nat Genet. 2018. PMID: 30224647 Free PMC article.
MOF-associated complexes ensure stem cell identity and Xist repression.
Chelmicki T, Dündar F, Turley MJ, Khanam T, Aktas T, Ramírez F, Gendrel AV, Wright PR, Videm P, Backofen R, Heard E, Manke T, Akhtar A. Chelmicki T, et al. Among authors: aktas t. Elife. 2014 May 19;3:e02024. doi: 10.7554/eLife.02024. Elife. 2014. PMID: 24842875 Free PMC article.
Transposons: catch them if you can.
Aktaş T. Aktaş T. Nat Rev Mol Cell Biol. 2022 May;23(5):306. doi: 10.1038/s41580-022-00470-1. Epub 2022 Mar 9. Nat Rev Mol Cell Biol. 2022. PMID: 35264767 Free PMC article.
Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik IA, Yung PYK, Navarro C, Bolondi A, Kumar AS, Anania C, Brändl B, Meierhofer D, Lupiáñez DG, Müller FJ, Aktas T, Elsässer SJ, Kretzmer H, Smith ZD, Meissner A. Weigert R, et al. Among authors: aktas t. Nat Cell Biol. 2023 Apr;25(4):579-591. doi: 10.1038/s41556-023-01114-y. Epub 2023 Apr 6. Nat Cell Biol. 2023. PMID: 37024684 Free PMC article.
Autonomous transposons tune their sequences to ensure somatic suppression.
Ilık İA, Glažar P, Tse K, Brändl B, Meierhofer D, Müller FJ, Smith ZD, Aktaş T. Ilık İA, et al. Among authors: aktas t. Nature. 2024 Feb;626(8001):1116-1124. doi: 10.1038/s41586-024-07081-0. Epub 2024 Feb 14. Nature. 2024. PMID: 38355802 Free PMC article.
TET activity safeguards pluripotency throughout embryonic dormancy.
Stötzel M, Cheng CY, IIik IA, Kumar AS, Omgba PA, van der Weijden VA, Zhang Y, Vingron M, Meissner A, Aktaş T, Kretzmer H, Bulut-Karslioğlu A. Stötzel M, et al. Among authors: aktas t. Nat Struct Mol Biol. 2024 Oct;31(10):1625-1639. doi: 10.1038/s41594-024-01313-7. Epub 2024 May 23. Nat Struct Mol Biol. 2024. PMID: 38783076 Free PMC article.
KAP1 controls endogenous retroviruses in embryonic stem cells.
Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D. Rowe HM, et al. Among authors: aktas t. Nature. 2010 Jan 14;463(7278):237-40. doi: 10.1038/nature08674. Nature. 2010. PMID: 20075919
46 results