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Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors.
Lipovšek D, Carvajal I, Allentoff AJ, Barros A Jr, Brailsford J, Cong Q, Cotter P, Gangwar S, Hollander C, Lafont V, Lau WL, Li W, Moreta M, O'Neil S, Pinckney J, Smith MJ, Su J, Terragni C, Wallace MA, Wang L, Wright M, Marsh HN, Bryson JW. Lipovšek D, et al. Among authors: gangwar s. Protein Eng Des Sel. 2018 May 1;31(5):159-171. doi: 10.1093/protein/gzy013. Protein Eng Des Sel. 2018. PMID: 30247737 Free PMC article.
Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody-Drug Conjugate.
Cheng H, Cong Q, Dervin D, Stevens A, Vemuri K, Huber M, Juliano J, Cuison S, Sung J, Passmore D, Chong C, Greenbaum M, Kwok E, Jiang J, Pan C, Rao-Naik C, Rangan V, Kempe T, Tatum A, Deshpande S, Cardarelli P, Vite G, Gangwar S. Cheng H, et al. Among authors: gangwar s. Bioconjug Chem. 2020 Oct 21;31(10):2350-2361. doi: 10.1021/acs.bioconjchem.0c00429. Epub 2020 Sep 11. Bioconjug Chem. 2020. PMID: 32881482
Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies.
Kotapati S, Passmore D, Yamazoe S, Sanku RKK, Cong Q, Poudel YB, Chowdari NS, Gangwar S, Rao C, Rangan VS, Cardarelli PM, Deshpande S, Strop P, Dollinger G, Rajpal A. Kotapati S, et al. Among authors: gangwar s. Anal Chem. 2020 Jan 21;92(2):2065-2073. doi: 10.1021/acs.analchem.9b04572. Epub 2020 Jan 6. Anal Chem. 2020. PMID: 31860282
Antibody-drug conjugates: current status and future directions.
Perez HL, Cardarelli PM, Deshpande S, Gangwar S, Schroeder GM, Vite GD, Borzilleri RM. Perez HL, et al. Among authors: gangwar s. Drug Discov Today. 2014 Jul;19(7):869-81. doi: 10.1016/j.drudis.2013.11.004. Epub 2013 Nov 15. Drug Discov Today. 2014. PMID: 24239727 Review.
Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.
Chowdari NS, Zhang Y, McDonald I, Johnson W, Langley DR, Sivaprakasam P, Mate R, Huynh T, Kotapati S, Deshpande M, Pan C, Menezes D, Wang Y, Rao C, Sarma G, Warrack BM, Rangan VS, Mei-Chen S, Cardarelli P, Deshpande S, Passmore D, Rampulla R, Mathur A, Borzilleri R, Rajpal A, Vite G, Gangwar S. Chowdari NS, et al. Among authors: gangwar s. J Med Chem. 2020 Nov 25;63(22):13913-13950. doi: 10.1021/acs.jmedchem.0c01385. Epub 2020 Nov 6. J Med Chem. 2020. PMID: 33155811
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Poudel YB, Rao C, Kotapati S, Deshpande M, Thevanayagam L, Pan C, Cardarelli J, Chowdari N, Kaspady M, Samikannu R, Kuppusamy P, Saravanakumar P, Arunachalam PN, Deshpande S, Rangan V, Rampulla R, Mathur A, Vite GD, Gangwar S. Poudel YB, et al. Among authors: gangwar s. Bioorg Med Chem Lett. 2020 Jan 1;30(1):126782. doi: 10.1016/j.bmcl.2019.126782. Epub 2019 Nov 9. Bioorg Med Chem Lett. 2020. PMID: 31767265
Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans.
Wang H, Rangan VS, Sung MC, Passmore D, Kempe T, Wang X, Thevanayagam L, Pan C, Rao C, Srinivasan M, Zhang Q, Gangwar S, Deshpande S, Cardarelli P, Marathe P, Yang Z. Wang H, et al. Among authors: gangwar s. Biopharm Drug Dispos. 2016 Mar;37(2):93-106. doi: 10.1002/bdd.1953. Epub 2015 May 15. Biopharm Drug Dispos. 2016. PMID: 25869904
76 results