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Page 1
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships.
Asquith CRM, East MP, Laitinen T, Alamillo-Ferrer C, Hartikainen E, Wells CI, Axtman AD, Drewry DH, Tizzard GJ, Poso A, Willson TM, Johnson GL. Asquith CRM, et al. Among authors: axtman ad. bioRxiv [Preprint]. 2023 Dec 28:2023.12.28.573261. doi: 10.1101/2023.12.28.573261. bioRxiv. 2023. Update in: Eur J Med Chem. 2024 May 5;271:116357. doi: 10.1016/j.ejmech.2024.116357 PMID: 38234837 Free PMC article. Updated. Preprint.
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD. Bashore FM, et al. Among authors: axtman ad. bioRxiv [Preprint]. 2024 May 14:2024.05.12.593776. doi: 10.1101/2024.05.12.593776. bioRxiv. 2024. Update in: ACS Med Chem Lett. 2024 Jul 03;15(8):1325-1333. doi: 10.1021/acsmedchemlett.4c00219 PMID: 38798634 Free PMC article. Updated. Preprint.
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD. Castano A, et al. Among authors: axtman ad. bioRxiv [Preprint]. 2023 Jun 16:2023.04.24.538049. doi: 10.1101/2023.04.24.538049. bioRxiv. 2023. Update in: Elife. 2023 Jul 25;12:e88206. doi: 10.7554/eLife.88206 PMID: 37162893 Free PMC article. Updated. Preprint.
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB. Agajanian MJ, et al. Among authors: axtman ad. Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023. Cell Rep. 2019. PMID: 30605688 Free PMC article.
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM, Drewry DH. Wells CI, et al. Among authors: axtman ad. Int J Mol Sci. 2021 Jan 8;22(2):566. doi: 10.3390/ijms22020566. Int J Mol Sci. 2021. PMID: 33429995 Free PMC article.
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.
Bashore FM, Marquez AB, Chaikuad A, Howell S, Dunn AS, Beltran AA, Smith JL, Drewry DH, Beltran AS, Axtman AD. Bashore FM, et al. Among authors: axtman ad. Sci Rep. 2023 Apr 14;13(1):6118. doi: 10.1038/s41598-023-32854-4. Sci Rep. 2023. PMID: 37059819 Free PMC article.
50 results