Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis.
Li WT, Luo QQ, Wang B, Chen X, Yan XJ, Qiu HY, Chen SL.
Li WT, et al. Among authors: wang b.
FASEB J. 2019 Feb;33(2):2435-2450. doi: 10.1096/fj.201800935RR. Epub 2018 Sep 27.
FASEB J. 2019.
PMID: 30260705
The findings show an MMC-dependent and FXR-mediated pronociceptive effect of BAs and identify the BA/FXR/NGF/TRPV1 axis as a key player in MMC-to-neuron communication during pain processing in IBS.-Li, W.-T., Luo, Q.-Q., Wang, B., Chen, X., Yan, X.-J., Qiu, H.-Y., C …
The findings show an MMC-dependent and FXR-mediated pronociceptive effect of BAs and identify the BA/FXR/NGF/TRPV1 axis as a key player in M …