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Role of Glycosyltransferases Modifying Type B Flagellin of Emerging Hypervirulent Clostridium difficile Lineages and Their Impact on Motility and Biofilm Formation.
Valiente E, Bouché L, Hitchen P, Faulds-Pain A, Songane M, Dawson LF, Donahue E, Stabler RA, Panico M, Morris HR, Bajaj-Elliott M, Logan SM, Dell A, Wren BW. Valiente E, et al. J Biol Chem. 2016 Dec 2;291(49):25450-25461. doi: 10.1074/jbc.M116.749523. Epub 2016 Oct 4. J Biol Chem. 2016. PMID: 27703012 Free PMC article.
We show that the glycosyltransferases 1 and 2 (GT1 and GT2) are responsible for the sequential addition of a GlcNAc and two rhamnoses, respectively, and that GT3 is associated with the incorporation of a novel sulfonated peptidyl-amido sugar moiety whose structure is reported in …
We show that the glycosyltransferases 1 and 2 (GT1 and GT2) are responsible for the sequential addition of a GlcNAc and two rhamnoses, respe …
The expression of free oligosaccharides in human seminal plasma.
Chalabi S, Easton RL, Patankar MS, Lattanzio FA, Morrison JC, Panico M, Morris HR, Dell A, Clark GF. Chalabi S, et al. J Biol Chem. 2002 Sep 6;277(36):32562-70. doi: 10.1074/jbc.M205152200. Epub 2002 Jun 12. J Biol Chem. 2002. PMID: 12063266 Free article.
O-glycosylation mimics N-glycosylation in the 16-kDa fragment of bovine pro-opiomelanocortin. The major O-glycan attached to Thr-45 carries SO4-4GalNAc beta 1-4GlcNAc beta 1-, which is the archetypal non-reducing epitope in the N-glycans of pituitary glycohormones.
Siciliano RA, Morris HR, Bennett HP, Dell A. Siciliano RA, et al. Among authors: morris hr. J Biol Chem. 1994 Jan 14;269(2):910-20. J Biol Chem. 1994. PMID: 7507111 Free article.
Thus O-glycosylation is likely to play an important role in controlling the fate of the NH2-terminal portion of pro-opiomelanocortin, thereby affecting the biological events that are influenced by peptides and glycopeptides derived from this domain. In a recent study (Siciliano, …
Thus O-glycosylation is likely to play an important role in controlling the fate of the NH2-terminal portion of pro-opiomelanocortin, thereb …
2,520 results