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Fisetin is a senotherapeutic that extends health and lifespan.
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: grassi d. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. EBioMedicine. 2018. PMID: 30279143 Free PMC article.
Identification of HSP90 inhibitors as a novel class of senolytics.
Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD. Fuhrmann-Stroissnigg H, et al. Among authors: grassi d. Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z. Nat Commun. 2017. PMID: 28871086 Free PMC article.
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.
Nogueira-Recalde U, Lorenzo-Gómez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, Lotz M, Robbins PD, Domínguez E, Caramés B. Nogueira-Recalde U, et al. Among authors: grassi d. EBioMedicine. 2019 Jul;45:588-605. doi: 10.1016/j.ebiom.2019.06.049. Epub 2019 Jul 5. EBioMedicine. 2019. PMID: 31285188 Free PMC article.
Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging.
Dorronsoro A, Santiago FE, Grassi D, Zhang T, Lai RC, McGowan SJ, Angelini L, Lavasani M, Corbo L, Lu A, Brooks RW, Garcia-Contreras M, Stolz DB, Amelio A, Boregowda SV, Fallahi M, Reich A, Ricordi C, Phinney DG, Huard J, Lim SK, Niedernhofer LJ, Robbins PD. Dorronsoro A, et al. Among authors: grassi d. Aging Cell. 2021 Apr;20(4):e13337. doi: 10.1111/acel.13337. Epub 2021 Mar 16. Aging Cell. 2021. PMID: 33728821 Free PMC article.
221 results