Sheu KM - Search Results

1

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.

Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. Park JW, et al. Among authors: sheu km. Science. 2018 Oct 5;362(6410):91-95. doi: 10.1126/science.aat5749. Science. 2018. PMID: 30287662 Free PMC article.

2

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.

Tsoi J, Robert L, Paraiso K, Galvan C, Sheu KM, Lay J, Wong DJL, Atefi M, Shirazi R, Wang X, Braas D, Grasso CS, Palaskas N, Ribas A, Graeber TG. Tsoi J, et al. Among authors: sheu km. Cancer Cell. 2018 May 14;33(5):890-904.e5. doi: 10.1016/j.ccell.2018.03.017. Epub 2018 Apr 12. Cancer Cell. 2018. PMID: 29657129 Free PMC article.

3

A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.

Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. Smith BA, et al. Among authors: sheu km. Cell Rep. 2018 Sep 18;24(12):3353-3366.e5. doi: 10.1016/j.celrep.2018.08.062. Cell Rep. 2018. PMID: 30232014 Free PMC article.

4

Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.

Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. Balanis NG, et al. Among authors: sheu km. Cancer Cell. 2019 Jul 8;36(1):17-34.e7. doi: 10.1016/j.ccell.2019.06.005. Cancer Cell. 2019. PMID: 31287989 Free PMC article.

5

Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy.

Kim YJ, Sheu KM, Tsoi J, Abril-Rodriguez G, Medina E, Grasso CS, Torrejon DY, Champhekar AS, Litchfield K, Swanton C, Speiser DE, Scumpia PO, Hoffmann A, Graeber TG, Puig-Saus C, Ribas A. Kim YJ, et al. Among authors: sheu km. J Clin Invest. 2021 Jun 15;131(12):e145859. doi: 10.1172/JCI145859. J Clin Invest. 2021. PMID: 33914706 Free PMC article.

6

NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.

Cheng QJ, Ohta S, Sheu KM, Spreafico R, Adelaja A, Taylor B, Hoffmann A. Cheng QJ, et al. Among authors: sheu km. Science. 2021 Jun 18;372(6548):1349-1353. doi: 10.1126/science.abc0269. Science. 2021. PMID: 34140389 Free PMC article.

7

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.

Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG. Chen CC, et al. Among authors: sheu km. Cancer Cell. 2023 Dec 11;41(12):2066-2082.e9. doi: 10.1016/j.ccell.2023.10.009. Epub 2023 Nov 22. Cancer Cell. 2023. PMID: 37995683 Free PMC article.

8

Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression.

Sen S, Cheng Z, Sheu KM, Chen YH, Hoffmann A. Sen S, et al. Among authors: sheu km. Cell Syst. 2020 Feb 26;10(2):169-182.e5. doi: 10.1016/j.cels.2019.12.004. Epub 2020 Jan 22. Cell Syst. 2020. PMID: 31972132 Free PMC article.

9

Stimulus-specificity in the Responses of Immune Sentinel Cells.

Sheu K, Luecke S, Hoffmann A. Sheu K, et al. Curr Opin Syst Biol. 2019 Dec;18:53-61. doi: 10.1016/j.coisb.2019.10.011. Epub 2019 Nov 6. Curr Opin Syst Biol. 2019. PMID: 32864512 Free PMC article.

10

Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses.

Adelaja A, Taylor B, Sheu KM, Liu Y, Luecke S, Hoffmann A. Adelaja A, et al. Among authors: sheu km. Immunity. 2021 May 11;54(5):916-930.e7. doi: 10.1016/j.immuni.2021.04.011. Immunity. 2021. PMID: 33979588 Free PMC article.

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