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A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. Wang L, et al. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):563-572. doi: 10.1073/pnas.1915770117. Epub 2019 Dec 23. Proc Natl Acad Sci U S A. 2020. PMID: 31871155 Free PMC article.
Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.
Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. Mao Z, et al. Among authors: wang l. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203410119. doi: 10.1073/pnas.2203410119. Epub 2022 Jul 25. Proc Natl Acad Sci U S A. 2022. PMID: 35878026 Free PMC article.
Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy.
Bangayan NJ, Wang L, Burton Sojo G, Noguchi M, Cheng D, Ta L, Gunn D, Mao Z, Liu S, Yin Q, Riedinger M, Li K, Wu AM, Stoyanova T, Witte ON. Bangayan NJ, et al. Among authors: wang l. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2312374120. doi: 10.1073/pnas.2312374120. Epub 2023 Nov 14. Proc Natl Acad Sci U S A. 2023. PMID: 37963244 Free PMC article.
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG. Chen CC, et al. Among authors: wang l. Cancer Cell. 2023 Dec 11;41(12):2066-2082.e9. doi: 10.1016/j.ccell.2023.10.009. Epub 2023 Nov 22. Cancer Cell. 2023. PMID: 37995683 Free PMC article.
PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford D, Lee JK, Graeber T, Shirihai O, Witte O. Varuzhanyan G, et al. Among authors: wang l. bioRxiv [Preprint]. 2024 Jul 25:2024.04.09.588489. doi: 10.1101/2024.04.09.588489. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121 PMID: 38645232 Free PMC article. Updated. Preprint.
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. Varuzhanyan G, et al. Among authors: wang l. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589879 Free PMC article.
Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses.
Harjunpää H, Somermäki R, Saldo Rubio G, Fusciello M, Feola S, Faisal I, Nieminen AI, Wang L, Llort Asens M, Zhao H, Eriksson O, Cerullo V, Fagerholm SC. Harjunpää H, et al. Among authors: wang l. Oncoimmunology. 2024 Jun 21;13(1):2369373. doi: 10.1080/2162402X.2024.2369373. eCollection 2024. Oncoimmunology. 2024. PMID: 38915784 Free PMC article.
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