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A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: alepee n. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
In vitro assessment of eye irritancy using the Reconstructed Human Corneal Epithelial SkinEthic HCE model: application to 435 substances from consumer products industry.
Cotovio J, Grandidier MH, Lelièvre D, Bremond C, Amsellem C, Maloug S, Ovigne JM, Loisel-Joubert S, Lee AV, Minondo AM, Capallere C, Bertino B, Alépée N, Tinois-Tessonneaud E, de Fraissinette Ade B, Meunier JR, Leclaire J. Cotovio J, et al. Among authors: alepee n. Toxicol In Vitro. 2010 Mar;24(2):523-37. doi: 10.1016/j.tiv.2009.11.010. Epub 2009 Nov 12. Toxicol In Vitro. 2010. PMID: 19913609
Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations.
Eskes C, Detappe V, Koëter H, Kreysa J, Liebsch M, Zuang V, Amcoff P, Barroso J, Cotovio J, Guest R, Hermann M, Hoffmann S, Masson P, Alépée N, Arce LA, Brüschweiler B, Catone T, Cihak R, Clouzeau J, D'Abrosca F, Delveaux C, Derouette JP, Engelking O, Facchini D, Fröhlicher M, Hofmann M, Hopf N, Molinari J, Oberli A, Ott M, Peter R, Sá-Rocha VM, Schenk D, Tomicic C, Vanparys P, Verdon B, Wallenhorst T, Winkler GC, Depallens O. Eskes C, et al. Among authors: alepee n. Regul Toxicol Pharmacol. 2012 Mar;62(2):393-403. doi: 10.1016/j.yrtph.2011.10.015. Epub 2011 Nov 6. Regul Toxicol Pharmacol. 2012. PMID: 22085589
Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods.
Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V. Adriaens E, et al. Among authors: alepee n. Arch Toxicol. 2014 Mar;88(3):701-23. doi: 10.1007/s00204-013-1156-8. Epub 2013 Dec 28. Arch Toxicol. 2014. PMID: 24374802 Free PMC article.
85 results