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HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. Kishinevsky S, et al. Among authors: chiosis g. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. Nat Commun. 2018. PMID: 30341316 Free PMC article.
Hsp90: the vulnerable chaperone.
Chiosis G, Vilenchik M, Kim J, Solit D. Chiosis G, et al. Drug Discov Today. 2004 Oct 15;9(20):881-8. doi: 10.1016/S1359-6446(04)03245-3. Drug Discov Today. 2004. PMID: 15475321 Review.
Emerging Hsp90 inhibitors: from discovery to clinic.
Chiosis G, Rodina A, Moulick K. Chiosis G, et al. Anticancer Agents Med Chem. 2006 Jan;6(1):1-8. doi: 10.2174/187152006774755483. Anticancer Agents Med Chem. 2006. PMID: 16475922 Review.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: chiosis g. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540
Discovery and development of heat shock protein 90 inhibitors.
Taldone T, Sun W, Chiosis G. Taldone T, et al. Among authors: chiosis g. Bioorg Med Chem. 2009 Mar 15;17(6):2225-35. doi: 10.1016/j.bmc.2008.10.087. Epub 2008 Nov 6. Bioorg Med Chem. 2009. PMID: 19017562 Free PMC article. Review.
179 results