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Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M. Oda T, et al. Among authors: nakamura y. J Mol Cell Cardiol. 2018 Dec;125:87-97. doi: 10.1016/j.yjmcc.2018.10.011. Epub 2018 Oct 22. J Mol Cell Cardiol. 2018. PMID: 30359562 Free PMC article.
Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.
Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M. Kato T, et al. Among authors: nakamura y. Heart Rhythm. 2017 Jan;14(1):120-127. doi: 10.1016/j.hrthm.2016.10.019. Epub 2016 Oct 19. Heart Rhythm. 2017. PMID: 27771553
Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.
Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M. Nishimura S, et al. Among authors: nakamura y. Heart Rhythm. 2018 Jun;15(6):905-914. doi: 10.1016/j.hrthm.2018.02.006. Epub 2018 Feb 7. Heart Rhythm. 2018. PMID: 29427818
Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.
Kajii T, Kobayashi S, Shiba S, Fujii S, Tamitani M, Kohno M, Nakamura Y, Nanno T, Kato T, Okuda S, Uchinoumi H, Oda T, Yamamoto T, Yano M. Kajii T, et al. Among authors: nakamura y. Biochem Biophys Res Commun. 2020 Jan 1;521(1):57-63. doi: 10.1016/j.bbrc.2019.10.071. Epub 2019 Oct 18. Biochem Biophys Res Commun. 2020. PMID: 31635807
Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress.
Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M. Tamitani M, et al. Among authors: nakamura y. Biochem Biophys Rep. 2020 Jul 21;23:100787. doi: 10.1016/j.bbrep.2020.100787. eCollection 2020 Sep. Biochem Biophys Rep. 2020. PMID: 32715106 Free PMC article.
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