Alayash AI - Search Results

1

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.

Jana S, Strader MB, Meng F, Hicks W, Kassa T, Tarandovskiy I, De Paoli S, Simak J, Heaven MR, Belcher JD, Vercellotti GM, Alayash AI. Jana S, et al. Among authors: alayash ai. JCI Insight. 2018 Nov 2;3(21):e120451. doi: 10.1172/jci.insight.120451. JCI Insight. 2018. PMID: 30385713 Free PMC article.

2

Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin.

Jia Y, Alayash AI. Jia Y, et al. Among authors: alayash ai. Free Radic Biol Med. 2008 Sep 1;45(5):659-66. doi: 10.1016/j.freeradbiomed.2008.05.010. Epub 2008 May 24. Free Radic Biol Med. 2008. PMID: 18539156

3

Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.

Abraham B, Hicks W, Jia Y, Baek JH, Miller JL, Alayash AI. Abraham B, et al. Among authors: alayash ai. Biochemistry. 2011 Nov 15;50(45):9752-66. doi: 10.1021/bi200876e. Epub 2011 Oct 21. Biochemistry. 2011. PMID: 21977904

4

Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)).

Mollan TL, Abraham B, Strader MB, Jia Y, Lozier JN, Olson JS, Alayash AI. Mollan TL, et al. Among authors: alayash ai. Protein Sci. 2012 Oct;21(10):1444-55. doi: 10.1002/pro.2130. Epub 2012 Aug 21. Protein Sci. 2012. PMID: 22821886 Free PMC article.

5

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Schaer DJ, et al. Among authors: alayash ai. Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Blood. 2013. PMID: 23264591 Free PMC article. Review.

6

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Belcher JD, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash AI, Smith A, Nath KA, Hebbel RP, Vercellotti GM. Belcher JD, et al. Among authors: alayash ai. Blood. 2014 Jan 16;123(3):377-90. doi: 10.1182/blood-2013-04-495887. Epub 2013 Nov 25. Blood. 2014. PMID: 24277079 Free PMC article.

7

Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.

Strader MB, Hicks WA, Kassa T, Singleton E, Soman J, Olson JS, Weiss MJ, Mollan TL, Wilson MT, Alayash AI. Strader MB, et al. Among authors: alayash ai. J Biol Chem. 2014 Aug 8;289(32):22342-57. doi: 10.1074/jbc.M114.568980. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939847 Free PMC article.

8

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.

Chintagari NR, Nguyen J, Belcher JD, Vercellotti GM, Alayash AI. Chintagari NR, et al. Among authors: alayash ai. Blood Cells Mol Dis. 2015 Mar;54(3):302-6. doi: 10.1016/j.bcmd.2014.12.001. Epub 2014 Dec 22. Blood Cells Mol Dis. 2015. PMID: 25582460 Free PMC article.

9

Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.

Ratanasopa K, Strader MB, Alayash AI, Bulow L. Ratanasopa K, et al. Among authors: alayash ai. Front Physiol. 2015 Feb 20;6:39. doi: 10.3389/fphys.2015.00039. eCollection 2015. Front Physiol. 2015. PMID: 25750627 Free PMC article.

10

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10).

Kassa T, Jana S, Strader MB, Meng F, Jia Y, Wilson MT, Alayash AI. Kassa T, et al. Among authors: alayash ai. J Biol Chem. 2015 Nov 13;290(46):27939-58. doi: 10.1074/jbc.M115.651257. Epub 2015 Sep 22. J Biol Chem. 2015. PMID: 26396189 Free PMC article.

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