Sheppard D - Search Results

1

Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.

Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Fong V, et al. Among authors: sheppard d. JCI Insight. 2018 Nov 2;3(21):e123578. doi: 10.1172/jci.insight.123578. JCI Insight. 2018. PMID: 30385725 Free PMC article.

2

Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.

Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Su G, et al. Among authors: sheppard d. Am J Respir Crit Care Med. 2012 Jan 1;185(1):58-66. doi: 10.1164/rccm.201108-1381OC. Am J Respir Crit Care Med. 2012. PMID: 21980034 Free PMC article.

3

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. Sugimoto K, et al. Among authors: sheppard d. J Clin Invest. 2012 Feb;122(2):748-58. doi: 10.1172/JCI58815. Epub 2012 Jan 9. J Clin Invest. 2012. PMID: 22232213 Free PMC article.

4

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. Kudo M, et al. Among authors: sheppard d. Nat Med. 2012 Mar 4;18(4):547-54. doi: 10.1038/nm.2684. Nat Med. 2012. PMID: 22388091 Free PMC article.

5

Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.

Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Su G, et al. Among authors: sheppard d. Crit Care Med. 2013 Feb;41(2):546-53. doi: 10.1097/CCM.0b013e3182711b1e. Crit Care Med. 2013. PMID: 23263571

6

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. Bhattacharya M, et al. Among authors: sheppard d. J Clin Invest. 2014 Nov;124(11):4895-8. doi: 10.1172/JCI76658. Epub 2014 Oct 1. J Clin Invest. 2014. PMID: 25271629 Free PMC article.

7

Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.

Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. Tsujino K, et al. Among authors: sheppard d. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L22-L31. doi: 10.1152/ajplung.00428.2016. Epub 2016 Nov 18. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 27864286 Free PMC article.

8

Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.

Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. Sundaram A, et al. Among authors: sheppard d. J Clin Invest. 2017 Jan 3;127(1):365-374. doi: 10.1172/JCI88555. Epub 2016 Dec 5. J Clin Invest. 2017. PMID: 27918306 Free PMC article.

9

Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.

Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. Tsujino K, et al. Among authors: sheppard d. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L878-L888. doi: 10.1152/ajplung.00062.2017. Epub 2017 Aug 17. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28818870 Free PMC article.

10

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. Liu S, et al. Among authors: sheppard d. J Clin Invest. 2021 Jun 15;131(12):e138140. doi: 10.1172/JCI138140. J Clin Invest. 2021. PMID: 33956668 Free PMC article.

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