Riad AA - Search Results

1

Synthesis and evaluation of an AZD2461 [¹⁸F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.

Reilly SW, Puentes LN, Schmitz A, Hsieh CJ, Weng CC, Hou C, Li S, Kuo YM, Padakanti P, Lee H, Riad AA, Makvandi M, Mach RH. Reilly SW, et al. Among authors: riad aa. Bioorg Chem. 2019 Mar;83:242-249. doi: 10.1016/j.bioorg.2018.10.015. Epub 2018 Oct 17. Bioorg Chem. 2019. PMID: 30390553 Free PMC article.

2

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.

Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Riad A, et al. Sci Rep. 2018 Nov 15;8(1):16845. doi: 10.1038/s41598-018-35430-3. Sci Rep. 2018. PMID: 30443021 Free PMC article.

3

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death.

Zeng C, Weng CC, Schneider ME Jr, Puentes L, Riad A, Xu K, Makvandi M, Jin L, Hawkins WG, Mach RH. Zeng C, et al. Cell Death Discov. 2019 Jan 28;5:58. doi: 10.1038/s41420-019-0141-2. eCollection 2019. Cell Death Discov. 2019. PMID: 30701090 Free PMC article.

4

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D₃ Receptor (D₃R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs).

Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Reilly SW, et al. Among authors: riad aa. J Med Chem. 2019 May 23;62(10):5132-5147. doi: 10.1021/acs.jmedchem.9b00412. Epub 2019 May 6. J Med Chem. 2019. PMID: 31021617

5

PARP-1-Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human Neuroblastoma.

Lee H, Riad A, Martorano P, Mansfield A, Samanta M, Batra V, Mach RH, Maris JM, Pryma DA, Makvandi M. Lee H, et al. J Nucl Med. 2020 Jun;61(6):850-856. doi: 10.2967/jnumed.119.233965. Epub 2019 Nov 1. J Nucl Med. 2020. PMID: 31676730 Free PMC article.

6

The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.

Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH. Riad A, et al. Mol Neurobiol. 2020 Sep;57(9):3803-3813. doi: 10.1007/s12035-020-01988-1. Epub 2020 Jun 23. Mol Neurobiol. 2020. PMID: 32572762 Free PMC article.

7

The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer.

Zeng C, Riad A, Mach RH. Zeng C, et al. Cancers (Basel). 2020 Jul 13;12(7):1877. doi: 10.3390/cancers12071877. Cancers (Basel). 2020. PMID: 32668577 Free PMC article. Review.

8

Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.

Izzo NJ, Colom-Cadena M, Riad AA, Xu J, Singh M, Abate C, Cahill MA, Spires-Jones TL, Bowen WD, Mach RH, Catalano SM. Izzo NJ, et al. Among authors: riad aa. eNeuro. 2020 Nov 4;7(6):ENEURO.0317-20.2020. doi: 10.1523/ENEURO.0317-20.2020. Print 2020 Nov/Dec. eNeuro. 2020. PMID: 33028631 Free PMC article. Review.

9

Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ₂R/TMEM97 ligands.

Xie XY, Li YY, Ma WH, Chen AF, Sun YT, Lee JY, Riad A, Xu DH, Mach RH, Huang YS. Xie XY, et al. Eur J Med Chem. 2021 Jan 1;209:112906. doi: 10.1016/j.ejmech.2020.112906. Epub 2020 Oct 7. Eur J Med Chem. 2021. PMID: 33049607

10

PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response.

Riad A, Gitto SB, Lee H, Winters HD, Martorano PM, Hsieh CJ, Xu K, Omran DK, Powell DJ Jr, Mach RH, Makvandi M. Riad A, et al. Molecules. 2020 Dec 19;25(24):6029. doi: 10.3390/molecules25246029. Molecules. 2020. PMID: 33352773 Free PMC article.

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