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Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D. Swatek KN, et al. Among authors: visser lj. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2371-2376. doi: 10.1073/pnas.1710617115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463763 Free PMC article.
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.
Visser LJ, Aloise C, Swatek KN, Medina GN, Olek KM, Rabouw HH, de Groot RJ, Langereis MA, de Los Santos T, Komander D, Skern T, van Kuppeveld FJM. Visser LJ, et al. PLoS Pathog. 2020 Jul 15;16(7):e1008702. doi: 10.1371/journal.ppat.1008702. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32667958 Free PMC article.
Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM. Rabouw HH, et al. Among authors: visser lj. Nat Microbiol. 2020 Nov;5(11):1361-1373. doi: 10.1038/s41564-020-0759-0. Epub 2020 Jul 20. Nat Microbiol. 2020. PMID: 32690955
15 results