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Page 1
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.
Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Ratnaparkhe M, et al. Among authors: wong jkl. Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4. Nat Commun. 2018. PMID: 30420702 Free PMC article.
The landscape of chromothripsis across adult cancer types.
Voronina N, Wong JKL, Hübschmann D, Hlevnjak M, Uhrig S, Heilig CE, Horak P, Kreutzfeldt S, Mock A, Stenzinger A, Hutter B, Fröhlich M, Brors B, Jahn A, Klink B, Gieldon L, Sieverling L, Feuerbach L, Chudasama P, Beck K, Kroiss M, Heining C, Möhrmann L, Fischer A, Schröck E, Glimm H, Zapatka M, Lichter P, Fröhling S, Ernst A. Voronina N, et al. Among authors: wong jkl. Nat Commun. 2020 May 8;11(1):2320. doi: 10.1038/s41467-020-16134-7. Nat Commun. 2020. PMID: 32385320 Free PMC article.
Chromothripsis in Human Breast Cancer.
Bolkestein M, Wong JKL, Thewes V, Körber V, Hlevnjak M, Elgaafary S, Schulze M, Kommoss FKF, Sinn HP, Anzeneder T, Hirsch S, Devens F, Schröter P, Höfer T, Schneeweiss A, Lichter P, Zapatka M, Ernst A. Bolkestein M, et al. Among authors: wong jkl. Cancer Res. 2020 Nov 15;80(22):4918-4931. doi: 10.1158/0008-5472.CAN-20-1920. Epub 2020 Sep 24. Cancer Res. 2020. PMID: 32973084
Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
Simovic M, Bolkestein M, Moustafa M, Wong JKL, Körber V, Benedetto S, Khalid U, Schreiber HS, Jugold M, Korshunov A, Hübschmann D, Mack N, Brons S, Wei PC, Breckwoldt MO, Heiland S, Bendszus M, Debus J, Höfer T, Zapatka M, Kool M, Pfister SM, Abdollahi A, Ernst A. Simovic M, et al. Among authors: wong jkl. Neuro Oncol. 2021 Dec 1;23(12):2028-2041. doi: 10.1093/neuonc/noab127. Neuro Oncol. 2021. PMID: 34049392 Free PMC article.
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.
Hanna BS, Llaó-Cid L, Iskar M, Roessner PM, Klett LC, Wong JKL, Paul Y, Ioannou N, Öztürk S, Mack N, Kalter V, Colomer D, Campo E, Bloehdorn J, Stilgenbauer S, Dietrich S, Schmidt M, Gabriel R, Rippe K, Feuerer M, Ramsay AG, Lichter P, Zapatka M, Seiffert M. Hanna BS, et al. Among authors: wong jkl. Immunity. 2021 Dec 14;54(12):2825-2841.e10. doi: 10.1016/j.immuni.2021.11.004. Epub 2021 Dec 7. Immunity. 2021. PMID: 34879221 Free article.
A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis.
Khalid U, Simovic M, Hammann LA, Iskar M, Wong JKL, Kumar R, Jugold M, Sill M, Bolkestein M, Kolb T, Hergt M, Devens F, Ecker J, Kool M, Milde T, Westermann F, Benner A, Lewis J, Dietrich S, Pfister SM, Lichter P, Zapatka M, Ernst A. Khalid U, et al. Among authors: wong jkl. Int J Cancer. 2022 Aug 15;151(4):590-606. doi: 10.1002/ijc.34027. Epub 2022 Apr 28. Int J Cancer. 2022. PMID: 35411591
33 results