Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes.
Song Z, Wang W, Li N, Yan S, Rong K, Lan T, Xia P.
Song Z, et al.
FASEB J. 2019 Mar;33(3):3636-3646. doi: 10.1096/fj.201801496R. Epub 2018 Nov 19.
FASEB J. 2019.
PMID: 30452878
Free PMC article.
These findings provide the first evidence, in vitro and in vivo, of a critical role for SK2 in mediating beta-cell lipotoxicity and the progression of diabetes.-Song, Z., Wang, W., Li, N., Yan, S., Rong, K., Lan, T., Xia, P. Sphingosine kinase 2 promotes lipotoxicit …
These findings provide the first evidence, in vitro and in vivo, of a critical role for SK2 in mediating beta-cell lipotoxicity and the prog …