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Page 1
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.
Nawrozkij MB, Forgione M, Yablokov AS, Lucidi A, Tomaselli D, Patsilinakos A, Panella C, Hailu GS, Kirillov IA, Badia R, Riveira-Muñoz E, Crespan E, Armijos Rivera JI, Cirilli R, Ragno R, Esté JA, Maga G, Mai A, Rotili D. Nawrozkij MB, et al. J Med Chem. 2019 Jan 24;62(2):604-621. doi: 10.1021/acs.jmedchem.8b01238. Epub 2018 Dec 20. J Med Chem. 2019. PMID: 30525601
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile.
Nawrozkij MB, Rotili D, Tarantino D, Botta G, Eremiychuk AS, Musmuca I, Ragno R, Samuele A, Zanoli S, Armand-Ugón M, Clotet-Codina I, Novakov IA, Orlinson BS, Maga G, Esté JA, Artico M, Mai A. Nawrozkij MB, et al. J Med Chem. 2008 Aug 14;51(15):4641-52. doi: 10.1021/jm800340w. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630898
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.
Rotili D, Samuele A, Tarantino D, Ragno R, Musmuca I, Ballante F, Botta G, Morera L, Pierini M, Cirilli R, Nawrozkij MB, Gonzalez E, Clotet B, Artico M, Esté JA, Maga G, Mai A. Rotili D, et al. Among authors: nawrozkij mb. J Med Chem. 2012 Apr 12;55(7):3558-62. doi: 10.1021/jm201308v. Epub 2012 Mar 26. J Med Chem. 2012. PMID: 22428851
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes.
Rotili D, Tarantino D, Nawrozkij MB, Babushkin AS, Botta G, Marrocco B, Cirilli R, Menta S, Badia R, Crespan E, Ballante F, Ragno R, Esté JA, Maga G, Mai A. Rotili D, et al. Among authors: nawrozkij mb. J Med Chem. 2014 Jun 26;57(12):5212-25. doi: 10.1021/jm500284x. Epub 2014 Jun 16. J Med Chem. 2014. PMID: 24933420
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
Bruno F, Errico S, Pace S, Nawrozkij MB, Mkrtchyan AS, Guida F, Maisto R, Olgaç A, D'Amico M, Maione S, De Rosa M, Banoglu E, Werz O, Fiorentino A, Filosa R. Bruno F, et al. Among authors: nawrozkij mb. Eur J Med Chem. 2018 Jul 15;155:946-960. doi: 10.1016/j.ejmech.2018.05.041. Epub 2018 May 28. Eur J Med Chem. 2018. PMID: 30015253
Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity.
Fioravanti R, Proia E, Tyurenkov IN, Kurkin DV, Bakulin DA, Kovalev NS, Sheikin DS, Kirillov IA, Nawrozkij MB, Vernigora AA, Brunilina LL, Fiorentino F, Mladenović M, Rotili D, Ragno R. Fioravanti R, et al. Among authors: nawrozkij mb. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114902. doi: 10.1016/j.ejmech.2022.114902. Epub 2022 Nov 12. Eur J Med Chem. 2023. PMID: 36403514
(Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling.
Golovina A, Proia E, Fiorentino F, Yunin M, Kasatkina M, Zigangirova N, Soloveva A, Sysolyatina E, Ermolaeva S, Novikov R, Silonov S, Pushkin S, Mladenović M, Isakova J, Belik A, Nawrozkij M, Rotili D, Ragno R, Ivanov R. Golovina A, et al. ACS Infect Dis. 2024 Jun 14;10(6):2127-2150. doi: 10.1021/acsinfecdis.4c00136. Epub 2024 May 21. ACS Infect Dis. 2024. PMID: 38771206
12 results