Giorgis M - Search Results

1

A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation.

Pellegrini C, Fornai M, Colucci R, Benvenuti L, D’Antongiovanni V, Natale G, Fulceri F, Giorgis M, Marini E, Gastaldi S, Bertinaria M, Blandizzi C, Antonioli L. Pellegrini C, et al. Among authors: giorgis m. Front Pharmacol. 2018 Dec 3;9:1405. doi: 10.3389/fphar.2018.01405. eCollection 2018. Front Pharmacol. 2018. PMID: 30559669 Free PMC article.

2

Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile.

Bertinaria M, Rolando B, Giorgis M, Montanaro G, Marini E, Collino M, Benetti E, Daniele PG, Fruttero R, Gasco A. Bertinaria M, et al. Among authors: giorgis m. Eur J Med Chem. 2012 Aug;54:103-12. doi: 10.1016/j.ejmech.2012.04.032. Epub 2012 May 2. Eur J Med Chem. 2012. PMID: 22626653 Free article.

3

Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis.

Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. Cocco M, et al. Among authors: giorgis m. J Med Chem. 2014 Dec 26;57(24):10366-82. doi: 10.1021/jm501072b. Epub 2014 Dec 4. J Med Chem. 2014. PMID: 25418070 Free article.

4

Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors.

Cocco M, Miglio G, Giorgis M, Garella D, Marini E, Costale A, Regazzoni L, Vistoli G, Orioli M, Massulaha-Ahmed R, Détraz-Durieux I, Groslambert M, Py BF, Bertinaria M. Cocco M, et al. Among authors: giorgis m. ChemMedChem. 2016 Aug 19;11(16):1790-803. doi: 10.1002/cmdc.201600055. Epub 2016 Mar 17. ChemMedChem. 2016. PMID: 26990578

5

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

Cocco M, Pellegrini C, Martínez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, López-Castejón G, Tapia-Abellán A, Angosto D, Hafner-Bratkovič I, Regazzoni L, Blandizzi C, Pelegrín P, Bertinaria M. Cocco M, et al. Among authors: giorgis m. J Med Chem. 2017 May 11;60(9):3656-3671. doi: 10.1021/acs.jmedchem.6b01624. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28410442

6

Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity.

Bertinaria M, Gastaldi S, Marini E, Giorgis M. Bertinaria M, et al. Among authors: giorgis m. Arch Biochem Biophys. 2019 Jul 30;670:116-139. doi: 10.1016/j.abb.2018.11.013. Epub 2018 Nov 16. Arch Biochem Biophys. 2019. PMID: 30448387 Free article. Review.

7

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor.

Gastaldi S, Boscaro V, Gianquinto E, Sandall CF, Giorgis M, Marini E, Blua F, Gallicchio M, Spyrakis F, MacDonald JA, Bertinaria M. Gastaldi S, et al. Among authors: giorgis m. Molecules. 2021 Jun 29;26(13):3975. doi: 10.3390/molecules26133975. Molecules. 2021. PMID: 34209843 Free PMC article.

8

Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study.

Marini E, Giorgis M, Leporati M, Rolando B, Chegaev K, Lazzarato L, Bertinaria M, Vincenti M, Di Stilo A. Marini E, et al. Among authors: giorgis m. Antioxidants (Basel). 2022 Jan 16;11(1):166. doi: 10.3390/antiox11010166. Antioxidants (Basel). 2022. PMID: 35052670 Free PMC article.

9

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF^V600E Protein.

Marini E, Marino M, Gionfriddo G, Maione F, Pandini M, Oddo D, Giorgis M, Rolando B, Blua F, Gastaldi S, Marchiò S, Kovachka S, Spyrakis F, Gianquinto E, Di Nicolantonio F, Bertinaria M. Marini E, et al. Among authors: giorgis m. Molecules. 2022 Dec 3;27(23):8513. doi: 10.3390/molecules27238513. Molecules. 2022. PMID: 36500607 Free PMC article.

10

Edaravone derivatives containing NO-donor functions.

Chegaev K, Cena C, Giorgis M, Rolando B, Tosco P, Bertinaria M, Fruttero R, Carrupt PA, Gasco A. Chegaev K, et al. Among authors: giorgis m. J Med Chem. 2009 Jan 22;52(2):574-8. doi: 10.1021/jm8007008. J Med Chem. 2009. PMID: 19113954 Free article.

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