Sebastian A - Search Results

1

One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems.

Srinivasulu V, Shehadeh I, Khanfar MA, Malik OG, Tarazi H, Abu-Yousef IA, Sebastian A, Baniowda N, O'Connor MJ, Al-Tel TH. Srinivasulu V, et al. Among authors: sebastian a. J Org Chem. 2019 Jan 18;84(2):934-948. doi: 10.1021/acs.joc.8b02878. Epub 2019 Jan 4. J Org Chem. 2019. PMID: 30582335

2

Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds.

Srinivasulu V, Schilf P, Ibrahim S, Khanfar MA, Sieburth SM, Omar H, Sebastian A, AlQawasmeh RA, O'Connor MJ, Al-Tel TH. Srinivasulu V, et al. Among authors: sebastian a. Nat Commun. 2018 Nov 26;9(1):4989. doi: 10.1038/s41467-018-07521-2. Nat Commun. 2018. PMID: 30478283 Free PMC article.

3

Domino Transformations of Ene/Yne Tethered Salicylaldehyde Derivatives: Pluripotent Platforms for the Construction of High sp³ Content and Privileged Architectures.

Sebastian A, Srinivasulu V, Abu-Yousef IA, Gorka O, Al-Tel TH. Sebastian A, et al. Chemistry. 2019 Dec 10;25(69):15710-15735. doi: 10.1002/chem.201902596. Epub 2019 Sep 20. Chemistry. 2019. PMID: 31365773 Review.

4

Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs.

Srinivasulu V, Khanfar M, Omar HA, ElAwady R, Sieburth SM, Sebastian A, Zaher DM, Al-Marzooq F, Hersi F, Al-Tel TH. Srinivasulu V, et al. Among authors: sebastian a. J Org Chem. 2019 Nov 15;84(22):14476-14486. doi: 10.1021/acs.joc.9b01919. Epub 2019 Oct 31. J Org Chem. 2019. PMID: 31633919

5

Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures.

Al-Tel TH, Srinivasulu V, Ramanathan M, Soares NC, Sebastian A, Bolognesi ML, Abu-Yousef IA, Majdalawieh A. Al-Tel TH, et al. Among authors: sebastian a. Org Biomol Chem. 2020 Nov 4;18(42):8526-8571. doi: 10.1039/d0ob01550d. Org Biomol Chem. 2020. PMID: 33043327 Review.

6

Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise.

Khaiwa N, Maarouf NR, Darwish MH, Alhamad DWM, Sebastian A, Hamad M, Omar HA, Orive G, Al-Tel TH. Khaiwa N, et al. Among authors: sebastian a. Eur J Med Chem. 2021 Nov 5;223:113639. doi: 10.1016/j.ejmech.2021.113639. Epub 2021 Jun 17. Eur J Med Chem. 2021. PMID: 34175539 Review.

7

Stereoselective Late-Stage Transformations of Indolo[2,3-a]quinolizines Skeleta to Nature-Inspired Scaffolds.

Srinivasulu V, Sieburth SM, Khanfar MA, Abu-Yousef IA, Majdalawieh A, Ramanathan M, Sebastian A, Al-Tel TH. Srinivasulu V, et al. Among authors: sebastian a. J Org Chem. 2021 Sep 17;86(18):12872-12885. doi: 10.1021/acs.joc.1c01523. Epub 2021 Sep 3. J Org Chem. 2021. PMID: 34477383

8

Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.

Srinivasulu V, Srikanth G, Khanfar MA, Abu-Yousef IA, Majdalawieh AF, Mazitschek R, Setty SC, Sebastian A, Al-Tel TH. Srinivasulu V, et al. Among authors: sebastian a. J Org Chem. 2022 Jan 21;87(2):1377-1397. doi: 10.1021/acs.joc.1c02698. Epub 2022 Jan 11. J Org Chem. 2022. PMID: 35014258

9

Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.

Abu Rabah RR, Sebastian A, Vunnam S, Sultan S, Tarazi H, Anbar HS, Shehata MK, Zaraei SO, Elgendy SM, Al Shamma SA, Omar HA, Al-Tel TH, El-Gamal MI. Abu Rabah RR, et al. Among authors: sebastian a. Bioorg Med Chem. 2022 Sep 1;69:116894. doi: 10.1016/j.bmc.2022.116894. Epub 2022 Jun 20. Bioorg Med Chem. 2022. PMID: 35764033

10

Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.

Sebastian A, Abu Rabah RR, Zaraei SO, Vunnam S, Sultan S, Anbar HS, El-Gamal R, Tarazi H, Sarg N, Alhamad DW, Al Shamma SA, Shahin AI, Omar HA, Al-Tel TH, El-Gamal MI. Sebastian A, et al. Eur J Med Chem. 2024 Aug 5;274:116557. doi: 10.1016/j.ejmech.2024.116557. Epub 2024 Jun 1. Eur J Med Chem. 2024. PMID: 38850857

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