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A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. Seeger T, et al. Among authors: wnorowski a. Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624. Circulation. 2019. PMID: 30586709 Free PMC article.
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy.
Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Sayed N, et al. Among authors: wnorowski a. Sci Transl Med. 2020 Jul 29;12(554):eaax9276. doi: 10.1126/scitranslmed.aax9276. Sci Transl Med. 2020. PMID: 32727917 Free PMC article.
Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction.
Tu C, Caudal A, Liu Y, Gorgodze N, Zhang H, Lam CK, Dai Y, Zhang A, Wnorowski A, Wu MA, Yang H, Abilez OJ, Lyu X, Narayan SM, Mestroni L, Taylor MRG, Recchia FA, Wu JC. Tu C, et al. Among authors: wnorowski a. Nat Biomed Eng. 2024 Apr;8(4):479-494. doi: 10.1038/s41551-023-01134-x. Epub 2023 Nov 27. Nat Biomed Eng. 2024. PMID: 38012305 Free PMC article.
Biodegradable external wrapping promotes favorable adaptation in an ovine vein graft model.
Ramachandra AB, Wang H, Wnorowski A, Schwarz EL, Pickering J, Heiler JC, Lucian HJ, Hironaka CE, Tran NA, Liu Y, Khan MO, Obafemi O, Tada Y, Kahn AM, Sayed N, Wu JC, Humphrey JD, Boyd JH, Marsden AL. Ramachandra AB, et al. Among authors: wnorowski a. Acta Biomater. 2022 Oct 1;151:414-425. doi: 10.1016/j.actbio.2022.08.029. Epub 2022 Aug 20. Acta Biomater. 2022. PMID: 35995404 Free PMC article.
93 results