Kao AW - Search Results

1

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.

Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW. Butler VJ, et al. Among authors: kao aw. Hum Mol Genet. 2019 May 1;28(9):1498-1514. doi: 10.1093/hmg/ddy442. Hum Mol Genet. 2019. PMID: 30590647 Free PMC article.

2

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW. Salazar DA, et al. Among authors: kao aw. J Neurosci. 2015 Jun 24;35(25):9315-28. doi: 10.1523/JNEUROSCI.4808-14.2015. J Neurosci. 2015. PMID: 26109656 Free PMC article.

3

The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.

Hsu TY, Butler VJ, Kao AW. Hsu TY, et al. Among authors: kao aw. Methods Mol Biol. 2018;1806:193-206. doi: 10.1007/978-1-4939-8559-3_14. Methods Mol Biol. 2018. PMID: 29956278

4

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.

Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. Yuan SH, et al. Among authors: kao aw. Hum Mol Genet. 2018 Nov 15;27(22):3951-3963. doi: 10.1093/hmg/ddy297. Hum Mol Genet. 2018. PMID: 30137327 Free PMC article.

5

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.

Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW. Butler VJ, et al. Among authors: kao aw. J Mol Biol. 2019 Mar 1;431(5):1038-1047. doi: 10.1016/j.jmb.2019.01.027. Epub 2019 Jan 25. J Mol Biol. 2019. PMID: 30690031 Free PMC article.

6

Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.

Butler VJ, Cortopassi WA, Gururaj S, Wang AL, Pierce OM, Jacobson MP, Kao AW. Butler VJ, et al. Among authors: kao aw. Biochemistry. 2019 Jun 11;58(23):2670-2674. doi: 10.1021/acs.biochem.9b00275. Epub 2019 May 24. Biochemistry. 2019. PMID: 31099551 Free PMC article.

7

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. Butler VJ, et al. Among authors: kao aw. PLoS Genet. 2019 Aug 9;15(8):e1008295. doi: 10.1371/journal.pgen.1008295. eCollection 2019 Aug. PLoS Genet. 2019. PMID: 31398187 Free PMC article.

8

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.

Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E. Tezil T, et al. Among authors: kao aw. NPJ Aging Mech Dis. 2019 Oct 2;5:7. doi: 10.1038/s41514-019-0037-7. eCollection 2019. NPJ Aging Mech Dis. 2019. PMID: 31602311 Free PMC article.

9

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW. Mohan S, et al. Among authors: kao aw. Mol Neurodegener. 2021 Aug 3;16(1):51. doi: 10.1186/s13024-021-00472-1. Mol Neurodegener. 2021. PMID: 34344440 Free PMC article.

10

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.

Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL, Kao AW. Alquezar C, et al. Among authors: kao aw. Sci Adv. 2021 Nov 5;7(45):eabg3897. doi: 10.1126/sciadv.abg3897. Epub 2021 Nov 5. Sci Adv. 2021. PMID: 34739309 Free PMC article.

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