Block DS - Search Results

1

A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity.

Zhang X, Owens J, Olsen HS, So E, Burch E, McCroskey MC, Li X, Weber GL, Bennett D, Rybin D, Zhou H, Hao H, Mérigeon EY, Block DS, LaRosa G, Strome SE. Zhang X, et al. Among authors: block ds. JCI Insight. 2019 Jan 24;4(2):e121905. doi: 10.1172/jci.insight.121905. JCI Insight. 2019. PMID: 30674715 Free PMC article.

2

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice.

Jain A, Olsen HS, Vyzasatya R, Burch E, Sakoda Y, Mérigeon EY, Cai L, Lu C, Tan M, Tamada K, Schulze D, Block DS, Strome SE. Jain A, et al. Among authors: block ds. Arthritis Res Ther. 2012 Aug 20;14(4):R192. doi: 10.1186/ar4024. Arthritis Res Ther. 2012. PMID: 22906120 Free PMC article.

3

Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer.

Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Mérigeon EY, Block DS, Zhang X, Schulze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L, Strome SE. Jain A, et al. Among authors: block ds. Eur J Cancer. 2013 Oct;49(15):3344-52. doi: 10.1016/j.ejca.2013.06.009. Epub 2013 Jul 18. Eur J Cancer. 2013. PMID: 23871153

4

Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease.

Zhang X, Olsen HS, Chen S, So E, Zhou H, Burch E, Mérigeon EY, Block DS, Strome SE. Zhang X, et al. Among authors: block ds. J Immunol. 2016 Feb 1;196(3):1165-76. doi: 10.4049/jimmunol.1501755. Epub 2015 Dec 22. J Immunol. 2016. PMID: 26695368

5

Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease.

Sun H, Olsen HS, Mérigeon EY, So E, Burch E, Kinsey S, Papadimitriou JC, Drachenberg CB, Bentzen SM, Block DS, Strome SE, Zhang X. Sun H, et al. Among authors: block ds. J Autoimmun. 2017 Nov;84:97-108. doi: 10.1016/j.jaut.2017.08.004. Epub 2017 Aug 19. J Autoimmun. 2017. PMID: 28830653

6

A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b.

Zhou H, Olsen H, So E, Mérigeon E, Rybin D, Owens J, LaRosa G, Block DS, Strome SE, Zhang X. Zhou H, et al. Among authors: block ds. Blood Adv. 2017 Mar 14;1(8):504-515. doi: 10.1182/bloodadvances.2016001917. eCollection 2017 Mar 14. Blood Adv. 2017. PMID: 29296968 Free PMC article.

7

An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.

Merigeon EY, Yang D, Ihms EA, Bassit LC, Fitzpatrick EA, Jonsson CB, Schinazi RF, Block DS, Olsen HS. Merigeon EY, et al. Among authors: block ds. Pathog Immun. 2022 Aug 23;7(1):104-121. doi: 10.20411/pai.v7i1.491. eCollection 2022. Pathog Immun. 2022. PMID: 36072571 Free PMC article.

8

Complement component C1q is an immunological rheostat that regulates Fc:Fc[Formula: see text]R interactions.

So EC, Zhou H, Greenwell A, Burch EE, Ji Y, Mérigeon EY, Olsen HS, Bentzen SM, Block DS, Zhang X, Strome SE. So EC, et al. Among authors: block ds. Immunogenetics. 2023 Aug;75(4):369-383. doi: 10.1007/s00251-023-01311-x. Epub 2023 Jun 15. Immunogenetics. 2023. PMID: 37322230

9

Fc multimers effectively treat murine models of multiple sclerosis.

Wang J, Brown K, Danehy C, Mérigeon E, Goralski S, Rice S, Torgbe K, Thomas F, Block D, Olsen H, Strome SE, Fitzpatrick EA. Wang J, et al. Front Immunol. 2023 Aug 11;14:1199747. doi: 10.3389/fimmu.2023.1199747. eCollection 2023. Front Immunol. 2023. PMID: 37638040 Free PMC article.

10

Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

Sattler R, Ayukawa Y, Coddington L, Sawa A, Block D, Chipkin R, Rothstein JD. Sattler R, et al. Exp Neurol. 2011 Dec;232(2):203-11. doi: 10.1016/j.expneurol.2011.09.002. Epub 2011 Sep 16. Exp Neurol. 2011. PMID: 21945230 Free PMC article. Clinical Trial.

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