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71 results

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Page 1
Host-Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism.
Ntountaniotis D, Andreadelis I, Kellici TF, Karageorgos V, Leonis G, Christodoulou E, Kiriakidi S, Becker-Baldus J, Stylos EK, Chatziathanasiadou MV, Chatzigiannis CM, Damalas DE, Aksoydan B, Javornik U, Valsami G, Glaubitz C, Durdagi S, Thomaidis NS, Kolocouris A, Plavec J, Tzakos AG, Liapakis G, Mavromoustakos T. Ntountaniotis D, et al. Among authors: liapakis g. Mol Pharm. 2019 Mar 4;16(3):1255-1271. doi: 10.1021/acs.molpharmaceut.8b01212. Epub 2019 Feb 13. Mol Pharm. 2019. PMID: 30681344
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.
Agelis G, Resvani A, Durdagi S, Spyridaki K, Tůmová T, Slaninová J, Giannopoulos P, Vlahakos D, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: liapakis g. Eur J Med Chem. 2012 Sep;55:358-74. doi: 10.1016/j.ejmech.2012.07.040. Epub 2012 Jul 31. Eur J Med Chem. 2012. PMID: 22889560
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: liapakis g. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C. Karampelas T, et al. Among authors: liapakis g. Bioconjug Chem. 2014 Apr 16;25(4):813-23. doi: 10.1021/bc500081g. Epub 2014 Apr 3. Bioconjug Chem. 2014. PMID: 24661240
An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism.
Ntountaniotis D, Agelis G, Resvani A, Halabalaki M, Liapakis G, Spyridaki K, Grdadolnik SG, Merzel F, Kostidis S, Potamitis C, Tselios T, Matsoukas J, Skaltsounis LA, Mavromoustakos T. Ntountaniotis D, et al. Among authors: liapakis g. Comb Chem High Throughput Screen. 2014;17(8):652-62. doi: 10.2174/138620731708140922171503. Comb Chem High Throughput Screen. 2014. PMID: 24875271
Rational drug design paradigms: the odyssey for designing better drugs.
Kellici T, Ntountaniotis D, Vrontaki E, Liapakis G, Moutevelis-Minakakis P, Kokotos G, Hadjikakou S, Tzakos AG, Afantitis A, Melagraki G, Bryant S, Langer T, Di Marzo V, Mavromoustakos T. Kellici T, et al. Among authors: liapakis g. Comb Chem High Throughput Screen. 2015;18(3):238-56. doi: 10.2174/1386207318666150305125638. Comb Chem High Throughput Screen. 2015. PMID: 25747445 Review.
Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor.
Kellici TF, Ntountaniotis D, Kritsi E, Zervou M, Zoumpoulakis P, Potamitis C, Durdagi S, Salmas RE, Ergun G, Gokdemir E, Halabalaki M, Gerothanassis IP, Liapakis G, Tzakos A, Mavromoustakos T. Kellici TF, et al. Among authors: liapakis g. Curr Med Chem. 2016;23(1):36-59. doi: 10.2174/0929867323666151117122116. Curr Med Chem. 2016. PMID: 26572611 Review.
Exploring new scaffolds for angiotensin II receptor antagonism.
Kritsi E, Matsoukas MT, Potamitis C, Karageorgos V, Detsi A, Magafa V, Liapakis G, Mavromoustakos T, Zoumpoulakis P. Kritsi E, et al. Among authors: liapakis g. Bioorg Med Chem. 2016 Sep 15;24(18):4444-4451. doi: 10.1016/j.bmc.2016.07.047. Epub 2016 Jul 22. Bioorg Med Chem. 2016. PMID: 27480029
71 results