Kahmann JD - Search Results

1

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Among authors: kahmann jd. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.

2

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.

Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M. Kahmann JD, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. doi: 10.1073/pnas.0308612100. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981270 Free PMC article.

3

Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.

Mesleh MF, Cross JB, Zhang J, Kahmann J, Andersen OA, Barker J, Cheng RK, Felicetti B, Wood M, Hadfield AT, Scheich C, Moy TI, Yang Q, Shotwell J, Nguyen K, Lippa B, Dolle R, Ryan MD. Mesleh MF, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1314-8. doi: 10.1016/j.bmcl.2016.01.009. Epub 2016 Jan 6. Bioorg Med Chem Lett. 2016. PMID: 26786695

4

Novel MK2 inhibitors by fragment screening.

Keminer O, Kraemer J, Kahmann J, Sternberger I, Scheich C, Jungmann J, Schaert S, Winkler D, Ichihara O, Whittaker M, Ullmann D, Hesterkamp T. Keminer O, et al. Comb Chem High Throughput Screen. 2009 Aug;12(7):697-703. doi: 10.2174/138620709788923700. Epub 2009 Aug 1. Comb Chem High Throughput Screen. 2009. PMID: 19531016

5

Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2.

Hereng TH, Backe PH, Kahmann J, Scheich C, Bjørås M, Skålhegg BS, Rosendal KR. Hereng TH, et al. J Struct Biol. 2012 Jun;178(3):300-10. doi: 10.1016/j.jsb.2012.03.013. Epub 2012 Apr 6. J Struct Biol. 2012. PMID: 22504716

6

Solution structure and peptide binding of the SH3 domain from human Fyn.

Morton CJ, Pugh DJ, Brown EL, Kahmann JD, Renzoni DA, Campbell ID. Morton CJ, et al. Among authors: kahmann jd. Structure. 1996 Jun 15;4(6):705-14. doi: 10.1016/s0969-2126(96)00076-7. Structure. 1996. PMID: 8805554 Free article.

7

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG. Teriete P, et al. Among authors: kahmann jd. Mol Cell. 2004 Feb 27;13(4):483-96. doi: 10.1016/s1097-2765(04)00080-2. Mol Cell. 2004. PMID: 14992719 Free article.

8

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

Kahmann JD, O'Brien R, Werner JM, Heinegârd D, Ladbury JE, Campbell ID, Day AJ. Kahmann JD, et al. Structure. 2000 Jul 15;8(7):763-74. doi: 10.1016/s0969-2126(00)00163-5. Structure. 2000. PMID: 10903951 Free article.

9

The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.

Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. Blundell CD, et al. Among authors: kahmann jd. J Biol Chem. 2003 Dec 5;278(49):49261-70. doi: 10.1074/jbc.M309623200. Epub 2003 Sep 11. J Biol Chem. 2003. PMID: 12972412 Free article.

10

Determining the molecular basis for the pH-dependent interaction between the link module of human TSG-6 and hyaluronan.

Blundell CD, Mahoney DJ, Cordell MR, Almond A, Kahmann JD, Perczel A, Taylor JD, Campbell ID, Day AJ. Blundell CD, et al. Among authors: kahmann jd. J Biol Chem. 2007 Apr 27;282(17):12976-88. doi: 10.1074/jbc.M611713200. Epub 2007 Feb 15. J Biol Chem. 2007. PMID: 17307731 Free article.

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