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545 results

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Page 1
Ultra-large library docking for discovering new chemotypes.
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Lyu J, et al. Among authors: roth bl. Nature. 2019 Feb;566(7743):224-229. doi: 10.1038/s41586-019-0917-9. Epub 2019 Feb 6. Nature. 2019. PMID: 30728502 Free PMC article.
Relating protein pharmacology by ligand chemistry.
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Keiser MJ, et al. Among authors: roth bl. Nat Biotechnol. 2007 Feb;25(2):197-206. doi: 10.1038/nbt1284. Nat Biotechnol. 2007. PMID: 17287757
Predicting new molecular targets for known drugs.
Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Keiser MJ, et al. Among authors: roth bl. Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1. Nature. 2009. PMID: 19881490 Free PMC article.
The presynaptic component of the serotonergic system is required for clozapine's efficacy.
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Among authors: roth bl. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.
Chemical informatics and target identification in a zebrafish phenotypic screen.
Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL Jr, Roth BL, Peterson RT, Shoichet BK. Laggner C, et al. Among authors: roth bl. Nat Chem Biol. 2011 Dec 18;8(2):144-6. doi: 10.1038/nchembio.732. Nat Chem Biol. 2011. PMID: 22179068 Free PMC article.
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Huang HS, et al. Among authors: roth bl. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726. Nature. 2011. PMID: 22190039 Free PMC article.
Identifying mechanism-of-action targets for drugs and probes.
Gregori-Puigjané E, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett L, Roth BL, Shoichet BK. Gregori-Puigjané E, et al. Among authors: roth bl. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11178-83. doi: 10.1073/pnas.1204524109. Epub 2012 Jun 18. Proc Natl Acad Sci U S A. 2012. PMID: 22711801 Free PMC article.
545 results