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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Rödström KEJ, Cloake A, Sörmann J, Baronina A, Smith KHM, Pike ACW, Ang J, Proks P, Schewe M, Holland-Kaye I, Bushell SR, Elliott J, Pardon E, Baukrowitz T, Owens RJ, Newstead S, Steyaert J, Carpenter EP, Tucker SJ. Rödström KEJ, et al. Among authors: cloake a. Nat Commun. 2024 May 16;15(1):4173. doi: 10.1038/s41467-024-48536-2. Nat Commun. 2024. PMID: 38755204 Free PMC article.
Structural basis of α-scorpion toxin action on Nav channels.
Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J. Clairfeuille T, et al. Among authors: cloake a. Science. 2019 Mar 22;363(6433):eaav8573. doi: 10.1126/science.aav8573. Epub 2019 Feb 7. Science. 2019. PMID: 30733386