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GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma.
Li Y, Fan Y, Xu J, Huo L, Scott AW, Jin J, Yang B, Shao S, Ma L, Wang Y, Yao X, Pool Pizzi M, Sewastjanow Da Silva M, Zhang G, Zhuo L, Cho EJ, Dalby KN, Shanbhag ND, Wang Z, Li W, Song S, Ajani JA. Li Y, et al. Among authors: li w. J Exp Clin Cancer Res. 2022 Aug 23;41(1):257. doi: 10.1186/s13046-022-02463-6. J Exp Clin Cancer Res. 2022. PMID: 35996148 Free PMC article.
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS. Li W, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1521-6. doi: 10.1073/pnas.1320638111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24434559 Free PMC article.
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.
Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, Ittmann MM, Gleave ME, Li W. Wang Z, et al. Among authors: li w, li l. Neoplasia. 2021 Nov;23(11):1147-1165. doi: 10.1016/j.neo.2021.09.005. Epub 2021 Oct 24. Neoplasia. 2021. PMID: 34706306 Free PMC article.
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