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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Aleo MD, Aubrecht J, D Bonin P, Burt DA, Colangelo J, Luo L, Schomaker S, Swiss R, Kirby S, C Rigdon G, Dua P. Aleo MD, et al. Among authors: c rigdon g. Pharmacol Res Perspect. 2019 Feb;7(1):e00467. doi: 10.1002/prp2.467. Pharmacol Res Perspect. 2019. PMID: 30784208 Free PMC article. Clinical Trial.