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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Aleo MD, Aubrecht J, D Bonin P, Burt DA, Colangelo J, Luo L, Schomaker S, Swiss R, Kirby S, C Rigdon G, Dua P. Aleo MD, et al. Among authors: luo l. Pharmacol Res Perspect. 2019 Feb;7(1):e00467. doi: 10.1002/prp2.467. Pharmacol Res Perspect. 2019. PMID: 30784208 Free PMC article. Clinical Trial.
Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein-Mediated Drug-Drug Interactions in Healthy Volunteers.
Miyake T, Kimoto E, Luo L, Mathialagan S, Horlbogen LM, Ramanathan R, Wood LS, Johnson JG, Le VH, Vourvahis M, Rodrigues AD, Muto C, Furihata K, Sugiyama Y, Kusuhara H. Miyake T, et al. Among authors: luo l. Clin Pharmacol Ther. 2021 Feb;109(2):507-516. doi: 10.1002/cpt.2022. Epub 2020 Oct 9. Clin Pharmacol Ther. 2021. PMID: 32866300 Free PMC article. Clinical Trial.
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