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Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability.
Bortoleti BTDS, Tomiotto-Pellissier F, Gonçalves MD, Miranda-Sapla MM, Assolini JP, Carloto AC, Lima DM, Silveira GF, Almeida RS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: carloto ac. Phytomedicine. 2019 Apr;57:262-270. doi: 10.1016/j.phymed.2018.12.035. Epub 2018 Dec 31. Phytomedicine. 2019. PMID: 30802712
Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Contato VM, Silva TF, de Matos RLN, Detoni MB, Rodrigues ACJ, Carloto AC, Lazarin DB, Arakawa NS, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: carloto ac. Phytomedicine. 2021 May;85:153536. doi: 10.1016/j.phymed.2021.153536. Epub 2021 Mar 3. Phytomedicine. 2021. PMID: 33765552
Solidagenone in vivo leishmanicidal activity acting in tissue repair response, and immunomodulatory capacity in Leishmania amazonensis.
Bortoleti BTDS, Detoni MB, Gonçalves MD, Tomiotto-Pellissier F, Silva TF, Concato VM, Rodrigues ACJ, Carloto AC, de Matos RLN, Fattori V, Arakawa NS, Verri WA Jr, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: carloto ac. Chem Biol Interact. 2022 Jul 1;361:109969. doi: 10.1016/j.cbi.2022.109969. Epub 2022 May 5. Chem Biol Interact. 2022. PMID: 35526601
Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTDS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EDS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: carloto acm. Phytomedicine. 2024 Jun;128:155536. doi: 10.1016/j.phymed.2024.155536. Epub 2024 Mar 13. Phytomedicine. 2024. PMID: 38513379
Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response.
Silva TF, Detoni MB, Concato-Lopes VM, Tomiotto-Pellissier F, Miranda-Sapla MM, Bortoleti BTDS, Gonçalves MD, Rodrigues ACJ, Sanfelice RA, Cruz EMS, Silva MSDS, Carloto ACM, Bidoia DL, Costa IN, Pavanelli WR, Conchon-Costa I. Silva TF, et al. Among authors: carloto acm. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167078. doi: 10.1016/j.bbadis.2024.167078. Epub 2024 Feb 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38364941
3,3',5,5'-Tetramethoxybiphenyl-4,4'diol triggers oxidative stress, metabolic changes, and apoptosis-like process by reducing the PI3K/AKT/NF-κB pathway in the NCI-H460 lung cancer cell line.
Concato-Lopes VM, Silva TF, Detoni MB, Cruz EMS, Gonçalves MD, da Silva Bortoleti BT, Tomiotto-Pellissier F, Carloto ACM, Madureira MB, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Dekker RFH, Conchon-Costa I, Panis C, Lazarin-Bidóia D, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: carloto acm. Biomed Pharmacother. 2024 Jan;170:115979. doi: 10.1016/j.biopha.2023.115979. Epub 2023 Dec 6. Biomed Pharmacother. 2024. PMID: 38061138 Free article.
Exploring the leishmanicidal potential of terpenoids: a comprehensive review on mechanisms of cell death.
Rodrigues ACJ, Carloto ACM, Gonçalves MD, Concato VM, Detoni MB, Dos Santos YM, Cruz EMS, Madureira MB, Nunes AP, Pires MFMK, Santos NC, Marques REDS, Bidoia DL, Borges Figueiredo F, Pavanelli WR. Rodrigues ACJ, et al. Among authors: carloto acm. Front Cell Infect Microbiol. 2023 Sep 19;13:1260448. doi: 10.3389/fcimb.2023.1260448. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37799331 Free PMC article. Review.
Synergistic Antileishmanial Effect of Oregano Essential Oil and Silver Nanoparticles: Mechanisms of Action on Leishmania amazonensis.
Alves AB, da Silva Bortoleti BT, Tomiotto-Pellissier F, Ganaza AFM, Gonçalves MD, Carloto ACM, Rodrigues ACJ, Silva TF, Nakazato G, Kobayashi RKT, Lazarin-Bidóia D, Miranda-Sapla MM, Costa IN, Pavanelli WR, Conchon-Costa I. Alves AB, et al. Among authors: carloto acm. Pathogens. 2023 Apr 29;12(5):660. doi: 10.3390/pathogens12050660. Pathogens. 2023. PMID: 37242330 Free PMC article.
Nanomedicine in leishmaniasis: A promising tool for diagnosis, treatment and prevention of disease - An update overview.
Assolini JP, Carloto ACM, Bortoleti BTDS, Gonçalves MD, Tomiotto Pellissier F, Feuser PE, Cordeiro AP, Hermes de Araújo PH, Sayer C, Miranda Sapla MM, Pavanelli WR. Assolini JP, et al. Among authors: carloto acm. Eur J Pharmacol. 2022 May 15;923:174934. doi: 10.1016/j.ejphar.2022.174934. Epub 2022 Mar 31. Eur J Pharmacol. 2022. PMID: 35367420 Review.
21 results