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Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability.
Bortoleti BTDS, Tomiotto-Pellissier F, Gonçalves MD, Miranda-Sapla MM, Assolini JP, Carloto AC, Lima DM, Silveira GF, Almeida RS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Phytomedicine. 2019 Apr;57:262-270. doi: 10.1016/j.phymed.2018.12.035. Epub 2018 Dec 31. Phytomedicine. 2019. PMID: 30802712
Brazilian propolis antileishmanial and immunomodulatory effects.
da Silva SS, Thomé Gda S, Cataneo AH, Miranda MM, Felipe I, Andrade CG, Watanabe MA, Piana GM, Sforcin JM, Pavanelli WR, Conchon-Costa I. da Silva SS, et al. Evid Based Complement Alternat Med. 2013;2013:673058. doi: 10.1155/2013/673058. Epub 2013 May 16. Evid Based Complement Alternat Med. 2013. PMID: 23762152 Free PMC article.
Nitric oxide and Brazilian propolis combined accelerates tissue repair by modulating cell migration, cytokine production and collagen deposition in experimental leishmaniasis.
Miranda MM, Panis C, Cataneo AH, da Silva SS, Kawakami NY, Lopes LG, Morey AT, Yamauchi LM, Andrade CG, Cecchini R, da Silva JJ, Sforcin JM, Conchon-Costa I, Pavanelli WR. Miranda MM, et al. PLoS One. 2015 May 14;10(5):e0125101. doi: 10.1371/journal.pone.0125101. eCollection 2015. PLoS One. 2015. PMID: 25973801 Free PMC article.
Sodium nitroprusside has leishmanicidal activity independent of iNOS.
Kawakami NY, Tomiotto-Pellissier F, Cataneo AH, Orsini TM, Thomazelli AP, Panis C, Conchon-Costa I, Pavanelli WR. Kawakami NY, et al. Rev Soc Bras Med Trop. 2016 Feb;49(1):68-73. doi: 10.1590/0037-8682-0266-2015. Rev Soc Bras Med Trop. 2016. PMID: 27163566 Free article.
Isolation of dengue virus serotype 4 genotype II from a patient with high viral load and a mixed Th1/Th17 inflammatory cytokine profile in South Brazil.
Kuczera D, Bavia L, Mosimann AL, Koishi AC, Mazzarotto GA, Aoki MN, Mansano AM, Tomeleri EI, Costa Junior WL, Miranda MM, Lo Sarzi M, Pavanelli WR, Conchon-Costa I, Duarte Dos Santos CN, Bordignon J. Kuczera D, et al. Virol J. 2016 Jun 6;13:93. doi: 10.1186/s12985-016-0548-9. Virol J. 2016. PMID: 27267473 Free PMC article.
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis.
Dos Santos Thomazelli APF, Tomiotto-Pellissier F, da Silva SS, Panis C, Orsini TM, Cataneo AHD, Miranda-Sapla MM, Custódio LA, Tatakihara VLH, Bordignon J, Silveira GF, Sforcin JM, Pavanelli WR, Conchon-Costa I. Dos Santos Thomazelli APF, et al. Cell Immunol. 2017 Jan;311:22-27. doi: 10.1016/j.cellimm.2016.09.014. Epub 2016 Sep 29. Cell Immunol. 2017. PMID: 27702443
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