Hayden M - Search Results

1

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1^G93A Model.

Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E. Ionescu A, et al. Among authors: hayden m. Cell Death Dis. 2019 Mar 1;10(3):210. doi: 10.1038/s41419-019-1451-2. Cell Death Dis. 2019. PMID: 30824685 Free PMC article.

2

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Eddings CR, Arbez N, Akimov S, Geva M, Hayden MR, Ross CA. Eddings CR, et al. Among authors: hayden mr. Neurobiol Dis. 2019 Sep;129:118-129. doi: 10.1016/j.nbd.2019.05.009. Epub 2019 May 17. Neurobiol Dis. 2019. PMID: 31108174 Free PMC article.

3

Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study.

McGarry A, Leinonen M, Kieburtz K, Geva M, Olanow CW, Hayden M. McGarry A, et al. Among authors: hayden m. J Huntingtons Dis. 2020;9(4):371-380. doi: 10.3233/JHD-200440. J Huntingtons Dis. 2020. PMID: 33164941 Free PMC article. Clinical Trial.

4

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I. Ryskamp D, et al. Among authors: hayden m. Neurobiol Dis. 2017 Jan;97(Pt A):46-59. doi: 10.1016/j.nbd.2016.10.006. Epub 2016 Nov 3. Neurobiol Dis. 2017. PMID: 27818324 Free PMC article.

5

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Ryskamp D, Wu L, Wu J, Kim D, Rammes G, Geva M, Hayden M, Bezprozvanny I. Ryskamp D, et al. Among authors: hayden m. Neurobiol Dis. 2019 Apr;124:489-504. doi: 10.1016/j.nbd.2018.12.022. Epub 2018 Dec 27. Neurobiol Dis. 2019. PMID: 30594810 Free PMC article.

6

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.

Francardo V, Geva M, Bez F, Denis Q, Steiner L, Hayden MR, Cenci MA. Francardo V, et al. Among authors: hayden mr. Neurotherapeutics. 2019 Apr;16(2):465-479. doi: 10.1007/s13311-018-00699-9. Neurotherapeutics. 2019. PMID: 30756361 Free PMC article.

7

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.

Naia L, Ly P, Mota SI, Lopes C, Maranga C, Coelho P, Gershoni-Emek N, Ankarcrona M, Geva M, Hayden MR, Rego AC. Naia L, et al. Among authors: hayden mr. Neurotherapeutics. 2021 Apr;18(2):1017-1038. doi: 10.1007/s13311-021-01022-9. Epub 2021 Apr 1. Neurotherapeutics. 2021. PMID: 33797036 Free PMC article.

8

Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor.

Shenkman M, Geva M, Gershoni-Emek N, Hayden MR, Lederkremer GZ. Shenkman M, et al. Among authors: hayden mr. J Neurochem. 2021 Jul;158(2):467-481. doi: 10.1111/jnc.15366. Epub 2021 Apr 28. J Neurochem. 2021. PMID: 33871049 Free article.

9

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.

Geva M, Gershoni-Emek N, Naia L, Ly P, Mota S, Rego AC, Hayden MR, Levin LA. Geva M, et al. Among authors: hayden mr. Sci Rep. 2021 Nov 9;11(1):21975. doi: 10.1038/s41598-021-01077-w. Sci Rep. 2021. PMID: 34753986 Free PMC article.

10

Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases.

Zhemkov V, Geva M, Hayden MR, Bezprozvanny I. Zhemkov V, et al. Among authors: hayden mr. Int J Mol Sci. 2021 Apr 15;22(8):4082. doi: 10.3390/ijms22084082. Int J Mol Sci. 2021. PMID: 33920913 Free PMC article.

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