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Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas.
Newman S, Fan L, Pribnow A, Silkov A, Rice SV, Lee S, Shao Y, Shaner B, Mulder H, Nakitandwe J, Shurtleff S, Azzato EM, Wu G, Zhou X, Barnhill R, Easton J, Nichols KE, Ellison DW, Downing JR, Pappo A, Potter PM, Zhang J, Bahrami A. Newman S, et al. Among authors: shurtleff s. Nat Med. 2019 Apr;25(4):597-602. doi: 10.1038/s41591-019-0373-y. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833747 Free PMC article.
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
Roussel MF, Shurtleff SA, Downing JR, Sherr CJ. Roussel MF, et al. Among authors: shurtleff sa. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6738-42. doi: 10.1073/pnas.87.17.6738. Proc Natl Acad Sci U S A. 1990. PMID: 2168557 Free PMC article.
121 results