Medema MH - Search Results

1

Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters.

Del Carratore F, Zych K, Cummings M, Takano E, Medema MH, Breitling R. Del Carratore F, et al. Among authors: medema mh. Commun Biol. 2019 Feb 28;2:83. doi: 10.1038/s42003-019-0333-6. eCollection 2019. Commun Biol. 2019. PMID: 30854475 Free PMC article.

2

Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis.

Tyc O, Kulkarni P, Ossowicki A, Tracanna V, Medema MH, van Baarlen P, van IJcken WFJ, Verhoeven KJF, Garbeva P. Tyc O, et al. Among authors: medema mh. mSystems. 2023 Feb 23;8(1):e0057422. doi: 10.1128/msystems.00574-22. Epub 2022 Dec 20. mSystems. 2023. PMID: 36537799 Free PMC article.

3

The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.

Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Müller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E. Medema MH, et al. Genome Biol Evol. 2010 Jul 12;2:212-24. doi: 10.1093/gbe/evq013. Genome Biol Evol. 2010. PMID: 20624727 Free PMC article.

4

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms.

Medema MH, Breitling R, Bovenberg R, Takano E. Medema MH, et al. Nat Rev Microbiol. 2011 Feb;9(2):131-7. doi: 10.1038/nrmicro2478. Epub 2010 Dec 29. Nat Rev Microbiol. 2011. PMID: 21189477 Review.

5

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus.

Medema MH, Alam MT, Heijne WH, van den Berg MA, Müller U, Trefzer A, Bovenberg RA, Breitling R, Takano E. Medema MH, et al. Microb Biotechnol. 2011 Mar;4(2):300-5. doi: 10.1111/j.1751-7915.2010.00226.x. Epub 2010 Nov 2. Microb Biotechnol. 2011. PMID: 21342474 Free PMC article.

6

Synthetic biology in Streptomyces bacteria.

Medema MH, Breitling R, Takano E. Medema MH, et al. Methods Enzymol. 2011;497:485-502. doi: 10.1016/B978-0-12-385075-1.00021-4. Methods Enzymol. 2011. PMID: 21601100

7

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.

Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R. Medema MH, et al. Nucleic Acids Res. 2011 Jul;39(Web Server issue):W339-46. doi: 10.1093/nar/gkr466. Epub 2011 Jun 14. Nucleic Acids Res. 2011. PMID: 21672958 Free PMC article.

8

Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.

Alam MT, Medema MH, Takano E, Breitling R. Alam MT, et al. Among authors: medema mh. FEBS Lett. 2011 Jul 21;585(14):2389-94. doi: 10.1016/j.febslet.2011.06.014. Epub 2011 Jun 22. FEBS Lett. 2011. PMID: 21712033 Free article.

9

The future of industrial antibiotic production: from random mutagenesis to synthetic biology.

Medema MH, Alam MT, Breitling R, Takano E. Medema MH, et al. Bioeng Bugs. 2011 Jul-Aug;2(4):230-3. doi: 10.1111/j.1751-7915.2010.00226.x. Epub 2011 Jul 1. Bioeng Bugs. 2011. PMID: 21829093

10

Computational tools for the synthetic design of biochemical pathways.

Medema MH, van Raaphorst R, Takano E, Breitling R. Medema MH, et al. Nat Rev Microbiol. 2012 Jan 23;10(3):191-202. doi: 10.1038/nrmicro2717. Nat Rev Microbiol. 2012. PMID: 22266781 Free article. Review.

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