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Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.
van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, Dolhain RJ, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Arthritis Rheum. 2011 Jan;63(1):73-83. doi: 10.1002/art.30093. Arthritis Rheum. 2011. PMID: 20954258 Free article.
TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation.
van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Cornelissen F, van Leeuwen JP, Hazes JM, Dolhain RJ, Bakx PA, Colin EM, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Ann Rheum Dis. 2012 Apr;71(4):606-12. doi: 10.1136/annrheumdis-2011-200424. Epub 2012 Jan 4. Ann Rheum Dis. 2012. PMID: 22219138
IL-17/Th17 mediated synovial inflammation is IL-22 independent.
van Hamburg JP, Corneth OB, Paulissen SM, Davelaar N, Asmawidjaja PS, Mus AM, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Ann Rheum Dis. 2013 Oct;72(10):1700-7. doi: 10.1136/annrheumdis-2012-202373. Epub 2013 Jan 17. Ann Rheum Dis. 2013. PMID: 23328939
127 results