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Activating PI3-kinase to dampen inflammation.
Kok BP, Saez E. Kok BP, et al. Among authors: saez e. Chem Biol. 2014 Aug 14;21(8):917-8. doi: 10.1016/j.chembiol.2014.07.012. Chem Biol. 2014. PMID: 25126986 Free PMC article.
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function.
Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR 3rd, Metallo CM, Sander M. Wortham M, et al. Among authors: saez e. Cell Rep. 2018 Dec 4;25(10):2904-2918.e8. doi: 10.1016/j.celrep.2018.11.031. Cell Rep. 2018. PMID: 30517875 Free PMC article.
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, Saghatelian A. Erikci Ertunc M, et al. Among authors: saez e. J Biol Chem. 2020 May 1;295(18):5891-5905. doi: 10.1074/jbc.RA119.012145. Epub 2020 Mar 9. J Biol Chem. 2020. PMID: 32152231 Free PMC article.
PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, Peluso JJ, Pru JK, Siuzdak G, Cravatt BF, Saez E. Galmozzi A, et al. Among authors: saez e. Nature. 2019 Dec;576(7785):138-142. doi: 10.1038/s41586-019-1774-2. Epub 2019 Nov 20. Nature. 2019. PMID: 31748741 Free PMC article.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Bar-Peled L, et al. Among authors: saez e. Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28. Cell. 2017. PMID: 28965760 Free PMC article.
157 results